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Merck

933570

NanoFabTx- Maleimide Lipid Mix

for synthesis of maleimide-functionalized liposomes

Synonyma:

Cholesterol, DSPC-PEG-Maleimide, HSPC

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O této položce

NACRES:
NA.21
UNSPSC Code:
12352211
Storage temp.:
−20°C
Technický servis
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Quality Segment

storage temp.

−20°C

Application

NanoFabTx Maleimide Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of maleimide-functionalized liposomes. Maleimide is a stable and easy-to-handle moiety that rapidly and covalently conjugates thiol groups of cysteine residues in proteins or peptides. This lipid mix enables users to encapsulate a wide variety of small molecules for targeting and immunotherapy applications without the need for lengthy trial-and-error optimization.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with maleimide groups using extrusion and microfluidics are also included. The synthesized maleimide-functionalized liposomes enable facile conjugation of targeting groups like proteins, peptides, and other thiol-containing moieties onto the liposome surface for targeted drug delivery.

Features and Benefits

  • A ready-to-use nanoformulation lipid blend for the synthesis of maleimide-functionalized liposomes
  • Step-by-step protocols developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
  • Maleimide surface functionalization allows for targeting ligand and protein conjugation to enable targeted drug delivery
Comprehensive protocols for liposome synthesis are included:

  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC


Skladovací třída

11 - Combustible Solids



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