679585

4-Methoxybenzyl-2,2,2-trichloroacetimidate

• Synonyma: p-Methoxybenzyl trichloroacetimidate
• Empirický vzorec (Hillův zápis): C₁₀H₁₀Cl₃NO₂
• Číslo CAS: 89238-99-3
• Molekulová hmotnost: 282.55
• NACRES: NA.22
• PubChem Substance ID: 24885502
• UNSPSC Code: 12352101
• MDL number: MFCD00134547

Vlastnosti

• Quality Segment: 100
• reaction suitability: reactivity: alcohol reactive, reagent type: protection reagent
• impurities: Major impurity is Trichloroacetamide by GCMS.
• refractive index: n20/D 1.5488
• bp: 135-137 °C/0.7 mmHg
• density: 1.361 g/mL at 25 °C
• functional group: chloro, ether
• storage temp.: 2-8°C
• SMILES string: COc1ccc(COC(=N)C(Cl)(Cl)Cl)cc1
• InChI: 1S/C10H10Cl3NO2/c1-15-8-4-2-7(3-5-8)6-16-9(14)10(11,12)13/h2-5,14H,6H2,1H3
• InChI key: TYHGKLBJBHACOI-UHFFFAOYSA-N

Popis

Application

4-Methoxybenzyl-2,2,2-trichloroacetimidate can be used as a reagent for the protection of alcohols as the p-methoxybenzyl ether. 1^o, 2^o, and 3^o alcohols can be easily protected using this reagent with equal efficiency in the presence of a variety of different protective groups. This reagent is commonly used under acidic conditions therefore it offers an alternative method to the Williamson ether synthesis, which is typically used basic conditions to protect base-sensitive alcohols.

Bezpečnostní informace

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302 + H312 + H332,H315,H319,H335,H411
• pcodes: P273 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Skladovací třída: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: >230.0 °F
• flash_point_c: > 110 °C