299634

6-(5H)-Phenanthridinone

technical grade

• Synonyma: NSC 11021, NSC 40943, NSC 61083
• Empirický vzorec (Hillův zápis): C₁₃H₉NO
• Číslo CAS: 1015-89-0
• Molekulová hmotnost: 195.22
• NACRES: NA.22
• PubChem Substance ID: 24858050
• UNSPSC Code: 12352100
• EC Number: 213-804-3
• MDL number: MFCD00004988
• Form: powder

Vlastnosti

• grade: technical grade
• Quality Segment: 100
• form: powder
• mp: 290-292 °C (lit.)
• SMILES string: O=C1Nc2ccccc2-c3ccccc13
• InChI: 1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)
• InChI key: RZFVLEJOHSLEFR-UHFFFAOYSA-N
• Gene Information: human ... PARP1(142)

Popis

General description

6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.

Application

Reactant involved in:

• Synthesis of 5,6-dihydrophenanthridine sulfonamides
• Oxidative coupling with diphenylacetylene
• Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides

Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including:

• Potassium channel KV1.3 and IK-1 inhibitors
• HIV-1 integrase inhibitors

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• Co se děje?: WGK 3
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable
• PPE (osobní ochranné prostředky): Eyeshields, Gloves, type N95 (US)