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Key Documents

T1539

Sigma-Aldrich

(+)-α-Tocopherol

Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000 IU/g

Synonym(s):

2,5,7,8-Tetramethyl-2-(4′,8′,12′-trimethyltridecyl)-6-chromanol, 5,7,8-Trimethyltocol, D-α-Tocopherol, Vitamin E

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About This Item

Empirical Formula (Hill Notation):
C29H50O2
CAS Number:
Molecular Weight:
430.71
Beilstein:
4712525
EC Number:
MDL number:
UNSPSC Code:
12352205
eCl@ss:
34058016
PubChem Substance ID:
NACRES:
NA.75

biological source

vegetable oil

Quality Level

type

Type VI

product line

BioReagent

form

liquid (≥0.88M based on potency, density and molecular wt.)

potency

≥600 mg d-α-tocopherol per g

specific activity

≥1000 IU/g

mol wt

Mw 430.71 g/mol

concentration

≥600 mg/g

technique(s)

cell culture | insect: suitable

color

yellow-orange

refractive index

n20/D 1.505 (lit.)

bp

200-220 °C/0.1 mmHg (lit.)

solubility

chloroform: soluble 0.1 mL/mL, clear, faintly yellow to yellow

density

0.95 g/mL at 25 °C (lit.)

format

neat

storage temp.

2-8°C

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1

InChI

1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1

InChI key

GVJHHUAWPYXKBD-IEOSBIPESA-N

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Application

Use in insect cell culture applications as an antioxidant.

Other Notes

Mixed constitutional (α, β, γ, δ) isomers.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

230.0 °F - closed cup

Flash Point(C)

110 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Ying Yang et al.
Food chemistry, 141(1), 473-481 (2013-06-19)
Vitamin E is an essential micronutrient for humans and animals due to its antioxidant and non-antioxidant biological activities. The α-tocopherol acetate form is often used in foods and other products due to its high biological activity and chemical stability. In
Jen-Hao Cheng et al.
European journal of medicinal chemistry, 46(4), 1222-1231 (2011-02-25)
In an effort to develop novel antioxidant as anticancer agents, a series of xanthones were prepared. In vitro screening, the synthetic xanthones revealed significant inhibitory effects on xanthine oxidase and ABTS radical-cation scavenging activity. The selective compounds 2 and 8
Karl Michaëlsson et al.
The American journal of clinical nutrition, 99(1), 107-114 (2013-11-15)
A reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting. The objective was to determine whether α-tocopherol intake or serum concentrations are associated with fracture risk in older women
Y Loetscher et al.
Poultry science, 92(11), 2938-2948 (2013-10-19)
Prevention of lipid oxidation needs special attention because a high proportion of fatty acids in broiler meat are unsaturated. A feeding experiment was conducted to evaluate the antioxidant effect of dietary addition of rosemary, chokeberry pomace, rosehip, or nettle in
Laura L Baxter et al.
Nutrients, 4(6), 467-490 (2012-07-24)
Vitamin E isoforms are essential nutrients that are widely used as dietary supplements and therapeutic agents for a variety of diseases. However, their pharmacokinetic (PK) properties remain poorly characterized, and high dosage animal studies may provide further information on their

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