SRP5255
HSP70, GST tagged human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
HSP70-1, HSP72, HSPA1, HSPA1A, HSPA1B. DAQB-147D11.1
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About This Item
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biological source
human
recombinant
expressed in E. coli
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
~96 kDa
NCBI accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... HSPA1A(3303)
General description
HSP70 is a member of the heat shock protein family and is synthesized by cells of many organisms in response to stress. HSP70 is found mostly but not exclusively in the nucleus of unstressed cells. For several hours after a short heat shock, however, it is strongly concentrated in nucleoli. Nucleoli are transiently damaged by such a heat shock: their morphology changes and assembly and export of ribosomes is blocked for several hours. HSP70 helps to stabilize the morphological changes of the nucleoli.
HSP70 (heat shock 70kDa)/Hsp70A1A (heat shock 70kDa protein 1A) is also termed as HSP72. It belongs to the molecular chaperones family. This gene is located on human chromosome 6p21.
HSP70 (heat shock 70kDa)/Hsp70A1A (heat shock 70kDa protein 1A) is also termed as HSP72. It belongs to the molecular chaperones family. This gene is located on human chromosome 6p21.
Biochem/physiol Actions
HSP70 (heat shock 70kDa)/Hsp70A1A (heat shock 70kDa protein 1A) participates in several cellular processes, such as thermotolerance, clearance of protein aggregate, survival and proliferation. Mutation in Hsp70 gene locus is linked with systemic lupus erythematosus. Overexpression of this protein is observed in valproic acid (VPA)-resistant cell lines.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Preparation Note
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus
Furnrohr BG, et al.
Annals of the Rheumatic Diseases, annrheumdis122630-annrheumdis122630 (2010)
The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients
Pae C U, et al.
Neuropsychobiology, 59(3), 135-141 (2009)
HSP72 functionally inhibits the anti-neoplastic effects of HDAC inhibitors
Fujii K, et al.
Journal of Dermatological Science, 90(1), 82-89 (2018)
Engagement of Components of DNA-Break Repair Complex and NF kappaB in Hsp70A1A Transcription Upregulation by Heat Shock
Hazra J, et al.
Testing, 12(1), e0168165-e0168165 (2017)
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