SML3147

GSK046

≥98% (HPLC)

• Synonym(s): iBET-BD2, 4-acetamido-3-fluoro-N-(trans-4-hydroxycyclohexyl)-5-[(1S)-1-phenylethoxy]benzamide; 4-Acetamido-3-fluoro-N-((1R,4S)-4-hydroxycyclohexyl)-5-((S)-1-phenylethoxy)benzamide
• Empirical Formula (Hill Notation): C₂₃H₂₇FN₂O₄
• CAS Number: 2474876-09-8
• Molecular Weight: 414.47
• MDL number: MFCD32858297
• UNSPSC Code: 12352107
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• storage temp.: 2-8°C
• SMILES string: O=C(N[C@H]1CC[C@H](O)CC1)C2=CC(F)=C(NC(C)=O)C(O[C@H](C3=CC=CC=C3)C)=C2
• InChI: 1S/C23H27FN2O4/c1-14(16-6-4-3-5-7-16)30-21-13-17(12-20(24)22(21)25-15(2)27)23(29)26-18-8-10-19(28)11-9-18/h3-7,12-14,18-19,28H,8-11H2,1-2H3,(H,25,27)(H,26,29)/t14-,18-,19-/m0/s1
• InChI key: FRBRZGLUFOZRGD-JVPBZIDWSA-N

Description

General description

GSK046 is an orally bioavailable small molecule. Its structure contains a poly-substituted phenyl ring in the center. GSK046 reduces immuno-inflammation by inhibiting the production of monocyte chemoattractant protein 1 (MCP-1), a chemokine involved in the regulation of macrophage activation.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable