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Key Documents

SML0773

Sigma-Aldrich

GSK-650394

≥98% (HPLC)

Synonym(s):

2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid, GSK 650394, GSK650394

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About This Item

Empirical Formula (Hill Notation):
C25H22N2O2
CAS Number:
890842-28-1
Molecular Weight:
382.45
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

InChI

1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)

InChI key

WVSBGSNVCDAMCF-UHFFFAOYSA-N

Application

GSK-650394 has been used as a serum and glucocorticoid-activated kinase (SGK1) inhibitor.

Biochem/physiol Actions

GSK-650394 has an IC50 value of 62 nM for serum and glucocorticoid-activated kinase-1 (SGK1) and 103 nM for SGK2. It has an ability to stop viral replication at concentrations that are nontoxic to cells.
GSK-650394 is a potent and selective Serum- and glucocorticoid-regulated kinase 1 (SGK1) antagonist.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Judith G Alamares-Sapuay et al.
Journal of virology, 87(10), 6020-6026 (2013-03-15)
We previously performed a small interfering RNA (siRNA) screen and identified serum- and glucocorticoid-regulated kinase 1 (SGK1) as a host factor required for influenza A virus replication. However, the role of SGK1 in the influenza viral life cycle has never
W Bruce Sneddon et al.
The Journal of biological chemistry, 291(36), 18632-18642 (2016-07-20)
Parathyroid hormone (PTH) and FGF23 are the primary hormones regulating acute phosphate homeostasis. Human renal proximal tubule cells (RPTECs) were used to characterize the mechanism and signaling pathways of PTH and FGF23 on phosphate transport and the role of the
Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport.
Sneddon WB
The Journal of Biological Chemistry, 291(36), 18632-18642 (2016)
Ferran Medina-Jover et al.
FEBS letters, 594(19), 3200-3215 (2020-08-09)
BMP9 is a cytokine involved in the maturation phase of the angiogenic process that signals through its serine/threonine receptor ALK1 and its coreceptor endoglin. In this paper, we explain how BMP9 directs the regulation of endothelial cell proliferation blockage while

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