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Key Documents

RAB0938

Sigma-Aldrich

Phosphotyrosine BTK / Tyrosine-protein Kinase BTK ELISA Kit

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

technique(s)

ELISA: suitable

assay range

inter-assay cv: <10%
intra-assay cv: <12%

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... BTK(695)

General description

Bruton tyrosine kinase (BTK) belongs to the Tec family of kinases. It is expressed in multiple hematopoietic cells. It plays a role in B-cell activation, maturation, development, and B-cell receptor (BCR)-signaling. Mutations in the BTK gene are associated with an inherited disorder, X-linked agammaglobulinemia. The BTK gene is located on the human chromosome at Xq22.1.
The antibody pair provided in this kit recognizes Human Tyrosine-Phosphorylated-BTK.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Kit Components Also Available Separately

Product No.
Description
SDS
  • RABHRP6Phosphotyrosine ELISA HRP-StreptavidinSDS

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Bruton's Tyrosine Kinase (BTK) Is a Novel KMT2A Partner Gene
Zerkalenkova E
Blood (2019)
Sarah E M Herman et al.
Blood, 117(23), 6287-6296 (2011-03-23)
B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and in knockout mouse models its mutation has a relatively B cell-specific phenotype. Herein, we demonstrate that BTK protein
Bruton's Tyrosine Kinase (BTK) Is a Novel KMT2A Partner Gene
Zerkalenkova E
Blood (2019)

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