P8014

4α-Phorbol 12,13-didecanoate

solid

• Synonym(s): 4α-Phorbol 12-13-dicaprinate, 4αPDD
• Empirical Formula (Hill Notation): C₄₀H₆₄O₈
• CAS Number: 27536-56-7
• Molecular Weight: 672.93
• Beilstein: 2514324
• MDL number: MFCD00036737
• UNSPSC Code: 12352211
• PubChem Substance ID: 24898900
• NACRES: NA.77

Properties

• form: solid
• Quality Level: 100
• color: white
• solubility: DMSO: soluble; ethanol: soluble; methanol: soluble
• storage temp.: −20°C
• SMILES string: CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(=O)CCCCCCCCC
• InChI: 1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1
• InChI key: DGOSGFYDFDYMCW-OEFRVDPMSA-N

Description

Application

4α-Phorbol 12,13-didecanoate has been used as a transient receptor potential vanilloid 4 (TRPV4) agonist:

• to study its effects on Madin-Darby canine kidney (MDCK) cells
• to study its effects on Ca²⁺ influx in mice fallopian tubal cells
• to study its effects on hind paw swelling in mice

Biochem/physiol Actions

4α-Phorbol 12,13-didecanoate is a transient receptor potential vanilloid 4 (TRPV4) agonist. It promotes extracellular calcium influx into the cells.

Caution

Photosensitive

Reconstitution

Stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

Safety Information

• Pictograms: GHS06,GHS08,GHS05
• Signal Word: Danger
• Hazard Statements: H300 + H310 + H330,H314,H317,H334,H351
• Precautionary Statements: P201 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves