Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 is a G-protein-coupled receptor. The gene encoding it is localized on human chromosome 3q25.1.
Immunogen
peptide corresponding to amino acid residues 125-142 of human P2Y12. This epitope is highly homologous in rat and mouse (16/18 residues identical).
Application
Anti-Purinergic Receptor P2Y12 antibody produced in rabbit has been used in Western blotting.
Biochem/physiol Actions
Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 has a role in platelet aggregation induced by ADP. Dysfunctional mutations in the protein have been linked with bleeding disorders. Studies have indicated that mice deficient in the P2Y12 receptor show decreased tumor metastasis.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The Journal of biological chemistry, 292(33), 13867-13878 (2017-06-28)
Vascular inflammation and thrombosis require the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs). GPCR dimerization is a well-established phenomenon that can alter protomer function. In platelets and other cell types, protease-activated receptor-4
Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders.
Lecchi A
Hamostaseologie (2016)
Expression and Localization of Purinergic P2Y12 Receptor in Human Nasal Mucosa
Hideaki Shirasaki
Allergology International (2013)
Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion
Niamh M
BMC Cancer (2015)
Leukotriene E4 induces MUC5AC release from human airway epithelial NCI-H292 cells
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