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P186

Sigma-Aldrich

PD 123,319 di(trifluoroacetate) salt hydrate

powder, ≥98% (HPLC)

Synonym(s):

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate

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About This Item

Empirical Formula (Hill Notation):
C31H32N4O3 · 2C2HF3O2 · xH2O
CAS Number:
136676-91-0
Molecular Weight:
736.66 (anhydrous basis)
MDL number:
MFCD11046022
UNSPSC Code:
12352202
PubChem Substance ID:
24898250
NACRES:
NA.32

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

solubility

H2O: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CN(C)c1ccc(Cn2cnc3CN([C@@H](Cc23)C(O)=O)C(=O)C(c4ccccc4)c5ccccc5)cc1C

InChI

1S/C31H32N4O3.2C2HF3O2.H2O/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24;2*3-2(4,5)1(6)7;/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38);2*(H,6,7);1H2/t28-;;;/m0.../s1

InChI key

PTSUEYBWHKDYBS-FPCIESGBSA-N

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Application

PD123,319 di (trifluoroacetate) salt hydrate has been used in following experimental studies:
  • To determine the effect of Angiotensin II (Ang II) on alveolar fluid clearance (AFC).
  • To study the effect of PD123319 on AngII-induced abdominal aortic aneurysms (AAAs).
  • To study its effect on Ang II-induced LRP1 overexpression and function in vascular smooth muscle cells (VSMCs) culture.

Biochem/physiol Actions

PD123,319 di (trifluoroacetate) salt hydrate is a widely used angiotensin II subtype-2 receptor (AT2R) antagonist to study the role of AT2 receptor in vitro and in vivo. It increases the AngII-induced abdominal aortic aneurysms (AAAs) without interacting with AT2 receptor.

Caution

Hygroscopic

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The Role of Angiotensin II and Cyclic AMP in Alveolar Active Sodium Transport.
Ismael-Badarneh R
PLoS ONE, 10(7), e0134175-e0134175 (2015)
Kalhara R Menikdiwela et al.
Scientific reports, 9(1), 8481-8481 (2019-06-13)
The Renin Angiotensin System (RAS), a key regulator of blood pressure has been linked to metabolic disorders. We have previously reported that adipose overexpression of angiotensinogen in mice (Agt-Tg) induces obesity, in part mediated by adipose tissue inflammation, through yet unidentified
PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism.
Daugherty A
PLoS ONE, 8(4), e61849-e61849 (2013)
Angiotensin II's role in sodium lactate-induced panic-like responses in rats with repeated urocortin 1 injections into the basolateral amygdala: amygdalar angiotensin receptors and panic.
Johnson PL
Progress in Neuro-Psychopharmacology, 44, 248-256 (2013)
Stephen A Contag et al.
American journal of physiology. Renal physiology, 298(4), F847-F856 (2010-01-15)
Antenatal corticosteroids may have long-term effects on renal development which have not been clearly defined. Our objective was to compare the responses to intrarenal infusions of ANG II in two groups of year-old, male sheep: one group exposed to a
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