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M6940

Sigma-Aldrich

Modafinil

≥98% (HPLC)

Synonym(s):

2-[(Diphenylmethyl)sulfinyl]­acetamide

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About This Item

Empirical Formula (Hill Notation):
C15H15NO2S
CAS Number:
68693-11-8
Molecular Weight:
273.35
MDL number:
MFCD00868082
UNSPSC Code:
12352200
PubChem Substance ID:
24897132
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

drug control

USDEA Schedule IV

color

white

solubility

DMSO: >10 mg/mL

originator

Teva

SMILES string

NC(=O)CS(=O)C(c1ccccc1)c2ccccc2

InChI

1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)

InChI key

YFGHCGITMMYXAQ-UHFFFAOYSA-N

Gene Information

human ... SLC6A3(6531)
rat ... Slc6a3(24898)

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Biochem/physiol Actions

Modafinil is a central nervous system vigilance promoting agent, which posseses neuroprotective properties.

Features and Benefits

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H361d

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Triethyl phosphate ReagentPlus®, ≥99.8%

Sigma-Aldrich

538728

Triethyl phosphate

Modafinil solution 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

M-084

Modafinil solution

Kousuke Okimura et al.
Scientific reports, 11(1), 1843-1843 (2021-01-21)
At high latitudes, approximately 10% of people suffer from depression during the winter season, a phenomenon known as seasonal affective disorder (SAD). Shortened photoperiod and/or light intensity during winter season are risk factors for SAD, and bright light therapy is
Perrin Kwek et al.
European journal of pharmacology, 699(1-3), 132-140 (2012-12-12)
Modafinil is a wakefulness-promoting agent with possible beneficial effects for the management of addiction and in psychiatric conditions, but also with abuse potential of its own. The mechanism of action of modafinil remains unclear. We studied pharmacological mechanisms in the
K M Baradhi et al.
Transplantation proceedings, 45(2), 845-847 (2013-03-19)
Acute interstitial nephritis is a well-recognized cause of acute kidney injury in native kidneys. While the most common etiology being drug-induced, other causes are infectious, autoimmune, and idiopathic forms of disease. Drug-induced acute interstitial nephritis is not only uncommon in
Hypersomnia due to bilateral thalamic lesions: unexpected response to Modafinil.
I Zavalko et al.
European journal of neurology, 19(11), e125-e126 (2012-08-21)
Tristan Shuman et al.
Behavioural brain research, 235(2), 105-112 (2012-09-12)
Modafinil is a wake-promoting drug effective at enhancing alertness and attention with a variety of approved and off-label applications. The mechanism of modafinil is not well understood but initial studies indicated a limited abuse potential. A number of recent publications
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