Skip to Content
Merck
All Photos(1)

Key Documents

H6161

Sigma-Aldrich

[Gly14]-Humanin G human

≥95% (HPLC), powder

Synonym(s):

S14G-humanin, HNG

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

MDL number:
MFCD03787971
UNSPSC Code:
12352209
NACRES:
NA.32

biological source

human

Quality Level

200

Assay

≥95% (HPLC)

form

powder

mol wt

2654.2-2660.2 Da

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

activity assay: suitable

solubility

water: 1.00-1.04 mg/mL, clear, colorless

shipped in

dry ice

storage temp.

−20°C

Amino Acid Sequence

Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala

General description

Research area: Neuroscience

[Gly14]-humanin (HNG) belongs to the family of mitochondrial-derived peptides. HNG (humanin-G) is an analog of humanin, generated by S14G (serine-14-glycine) mutation. HNG shows a 1000 times stronger activity.

Application

[Gly14]-Humanin G human has been used:
  • along with bortezomib in pharmacological inhibition studies to treat mice to limit the toxic effects of bortezomib
  • to study its effect on high glucose (HG)-induced apoptosis of endothelial cells (ECs)
  • to study its neuroprotective effects in an in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) model using SH-SY5Y neuroblastoma cells
[Gly¹⁴]-Humanin G human has been used to limit the toxicity during the bortezomib treatment in neonatal brachial plexus injury (NBPI) mice model. It has also been used in the cell culture of the human-derived neuroblastoma cell line.

Biochem/physiol Actions

Endogenous rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer′s disease genes and Aβ
[Gly14]-humanin (HNG) stimulates cell growth, proliferation, and cell cycle progression. It enhances proteins such as kinases, transporters, transmembrane receptors, and transcription and translational regulators. HNG exhibits intense in vitro neuroprotective effects compared to natural HN. Studies show that it is an effective cytoprotectant both in vitro and in vivo. HNG is found to prevent high glucose (HG)-induced apoptosis of endothelial cells (ECs). It is proven to inhibit AngII-induced phenotypic switch in vascular smooth muscle cells (VSMCs).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

HNG, a humanin analogue, promotes hair growth by inhibiting anagen-to-catagen transition
Kim SM, et al.
International Journal of Molecular Sciences, 21 (2020)
Li Yuan et al.
Neuroscience bulletin, 32(4), 374-382 (2016-06-17)
Alzheimer disease (AD), a progressive neurodegenerative disorder, is characterized by cognitive decline and the accumulation of senile plaques in the brain. Amyloid β protein (Aβ) in the plaques is thought to be responsible for the memory loss in AD patients.
Qingnian Goh et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(2), e21214-e21214 (2020-11-26)
Neonatal brachial plexus injury (NBPI) causes disabling and incurable contractures, or limb stiffness, which result from proteasome-mediated protein degradation impairing the longitudinal growth of neonatally denervated muscles. We recently showed in a mouse model that the 20S proteasome inhibitor, bortezomib
Xin Wang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 110, 248-253 (2018-12-06)
Skin provides the protective barrier for our body and undergoes the continuous regeneration in order to overcome damage from exposure to harmful environments and wounds. Epidermal stem cells (ESCs) play critical roles in skin regeneration. Humanin analogue, S14G-humanin (HNG), a
Guangsheng Gao et al.
Neurological research, 39(10), 895-903 (2017-07-20)
Humanin (HN) has been identified to suppress neuron death. Gly Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups. Both GI group and HNG groups included six time points (1, 3, 6, 12, 24, and
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service