H5653

8-Hydroxy-2′-deoxyguanosine

≥98% (TLC), DNA damage biomaker

• Synonym(s): 8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG
• Empirical Formula (Hill Notation): C₁₀H₁₃N₅O₅
• CAS Number: 88847-89-6
• Molecular Weight: 283.24
• MDL number: MFCD00210311
• UNSPSC Code: 12352200
• PubChem Substance ID: 24895702
• NACRES: NA.77

Properties

• Product Name: 8-Hydroxy-2′-deoxyguanosine, ≥98% (TLC)
• Quality Level: 200
• Assay: ≥98% (TLC)
• storage temp.: 2-8°C
• SMILES string: O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1
• InChI: 1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)
• InChI key: HCAJQHYUCKICQH-UHFFFAOYSA-N

Description

Application

8-Hydroxy-2′-deoxyguanosine has been used:

• as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
• as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
• as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential antioxidant activity of green coffee bean extract (GCBE) in vivo
• as a standard for LC/MS/MS analysis

Biochem/physiol Actions

A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis

The levels of 8-hydroxy-2′-deoxyguanosine helps in evaluating oxidative stress and DNA damage in individuals suffering from laryngeal cancer. Hence it serves as a major biomarker of DNA damage, induced by reactive oxygen species (ROS).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves