GW20056A
Anti-Transcription Factor E3 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-TFE3, Anti-Transcription factor binding to IGHM enhancer 3
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
chicken
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
manufacturer/tradename
Genway 15-288-20056A
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TFE3(7030)
Immunogen
Immunogen Sequence: GI # 8659574, sequence 432-541
Recombinant transcription factor binding to IGHM enhancer 3
Application
Anti-Transcription Factor E3 antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.
Biochem/physiol Actions
TFE3 (Transcription factor E3) gene encodes a helix-loop-helix transcription factor that contains a helix-loop-helix domain and binds to MUE3-type E-box sequences (5′-CANNTG-3′). It plays a key role in transforming growth factor β (TGF-β) induced activation of the plasminogen activator inhibitor-1 (PAI-1) promoter. Chromosomal translocation resulting in the fusion of TFE3 gene to a novel gene, designated PRCC, is observed in papillary renal cell carcinomas. A chromosomal aberration in TFE3 is observed in patients with alveolar soft part sarcoma.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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J Clark et al.
Oncogene, 15(18), 2233-2239 (1997-12-11)
We demonstrate that the cytogenetically defined translocation t(X;1)(p11.2;p34) observed in papillary renal cell carcinomas results in the fusion of the splicing factor gene PSF located at 1p34 to the TFE3 helix-loop-helix transcription factor gene at Xp11.2. In addition we define
P Argani et al.
The American journal of pathology, 159(1), 179-192 (2001-07-05)
The unbalanced translocation, der(17)t(X;17)(p11.2;q25), is characteristic of alveolar soft part sarcoma (ASPS). We have recently shown that this translocation fuses the TFE3 transcription factor gene at Xp11.2 to ASPL, a novel gene at 17q25. We describe herein eight morphologically distinctive
X Hua et al.
Genes & development, 12(19), 3084-3095 (1998-10-09)
Members of the TGF-beta superfamily influence a broad range of biological activities including stimulation of wound healing and inhibition of cell growth. TGF-beta signals through type I and II receptor serine/ threonine kinases and induces transcription of many genes including
M A Weterman et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(26), 15294-15298 (1996-12-24)
The (X;1)(p11;q21) translocation is a recurrent chromosomal abnormality in a subset of human papillary renal cell carcinomas, and is sometimes the sole cytogenetic abnormality present. Via positional cloning, we were able to identify the genes involved. The translocation results in
H Beckmann et al.
Genes & development, 4(2), 167-179 (1990-02-01)
The muE3 motif within the immunoglobulin heavy-chain enhancer is required for full enhancer activity and is known to bind one, or perhaps a family, of related ubiquitous nuclear proteins. Here, we present the isolation of a cDNA that encodes an
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