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Key Documents

C3527

Sigma-Aldrich

Anti-C-Reactive Protein antibody produced in rabbit

IgG fraction of antiserum, lyophilized powder

Synonym(s):

Anti-CRP

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About This Item

MDL number:
MFCD00162183
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

packaging

vial of 2 mL lyophilized antiserum

technique(s)

indirect ELISA: 1:10,000-1:20,000

UniProt accession no.

P02741

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... CRP(1401)

General description

C-reactive protein (CRP) is an acute-phase pentraxin protein. It is synthesized by the liver. This gene is mapped to human chromosome 1q23. It has two exons and an intron. It is located within the complement membrane complex in early atherosclerotic tissue.

Application

Anti-C-Reactive Protein antibody produced in rabbit has been used in electro immunoassay, and enzyme-linked immunosorbent assay (ELISA).
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Enzyme-linked immunosorbent assay (1 paper)

Biochem/physiol Actions

C-reactive protein (CRP) is considered as a major biomarker of sterile inflammation. It is mainly used to observe the treatment response which can predict long-term consequence in inflammatory diseases. CRP facilitates opsonization of low-density lipoprotein by macrophages.

Physical form

Lyophilized from 0.01 M phosphate buffered saline, pH 7.2

Reconstitution

Reconstitute with 2 ml deionized water.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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C-Reactive Protein Production in Term Human Placental Tissue
Malek A, et al.
Placenta, 27(6), 619-625 (2006)
Protein and amino acid metabolism in three-to twelve-month-old infants fed human milk or formulas with varying protein concentrations
AAkeson PMK, et al.
Journal of Pediatric Gastroenterology and Nutrition, 26(3), 297-304 (1998)
Luigi Raio et al.
Journal of hypertension, 37(5), 1012-1017 (2019-03-19)
Angiogenic and inflammatory factors have been shown to play an important role in the pathogenesis of preeclampsia. However, there is little information on their interaction. The aims of this study were to investigate the longitudinal pattern of inflammatory markers, such
C-Reactive Protein Levels at the Midpregnancy Can Predict Gestational Complications
Vecchie A, et al.
BioMed Research International, 2018 (2018)
Concentrations of leptin and C-reactive protein in serum and follicular fluid during assisted reproductive cycles
Wunder DM, et al.
Human Reproduction, 20(5), 1266-1271 (2005)
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