C0984
Creatine Kinase MB Fraction from human heart
≥70% (SDS-PAGE), liquid
Synonym(s):
CK MB Fraction
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
biological source
human heart
Quality Level
Assay
≥70% (SDS-PAGE)
form
liquid
concentration
≥0.5 mg/mL
technique(s)
IR spectroscopy: suitable
suitability
suitable for tissue
application(s)
pharmaceutical
storage temp.
−20°C
Looking for similar products? Visit Product Comparison Guide
General description
Research area: Cell Signaling
Creatine Kinase (CK) comprises M and B subunit and is a dimeric molecule. It is one among the isoenzymes of CK. The enzyme is majorly present in the myocardium.
Creatine Kinase (CK) comprises M and B subunit and is a dimeric molecule. It is one among the isoenzymes of CK. The enzyme is majorly present in the myocardium.
Application
Creatine Kinase MB Fraction from human heart has been used:
- as a diagnostic marker for acute myocardial infarction.
- to identify overlapping absorbance peaks between blood and the cardiac biomarkers.
- to study the phosphorylation pathway of dioxolane guanosine (DXG) in vivo, a potential treatment of HIV-1 infection.
Biochem/physiol Actions
Creatine Kinase (CK) catalyzes the formation of creatinine from creatine phosphate. The enzyme is associated with coronary performance. Elevated serum levels of CK-MB are prime indicators of myocardial cellular injury. It is regarded as a “gold standard” for myocardial infarction diagnosis. The levels of cardiac troponin I (cTnI) or cardiac troponin T also correlate to higher CK-MB) levels. CK-MB levels may also be elevated in chronic renal failure.
Components
Solution in 5 mM sodium succinate, 10 mM sodium chloride, 1 mM EDTA, 5 mM β-mercaptoethanol, 50% glycerol, pH 7.0.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Development and preliminary validation of infrared spectroscopic device for transdermal assessment of elevated cardiac troponin
Titus J, et al.
Communications medicine, 2 (2022)
J E Adams et al.
Clinical chemistry, 40(7 Pt 1), 1291-1295 (1994-07-01)
Although measurement of cardiac troponin I (cTnI) is, in some situations, more specific for detection of cardiac injury than is measurement of the MB isoenzyme of creatine kinase (MBCK), its sensitivity and specificity relative to MBCK for detection of myocardial
Creatine Kinase
Clinical Methods: The History, Physical, and Laboratory Examinations (1990)
Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5?-phosphates by mammalian phosphotransferases
Feng JY, et al.
Biochemical Pharmacology, 68(9), 1879-1888 (2004)
Terry M Welsh et al.
Annals of clinical and laboratory science, 32(1), 44-49 (2002-02-19)
The diagnosis of myocardial infarction (MI) is established in patients with chest pain and equivocal electrocardiogram changes by demonstrating a rise in blood levels of creatine kinase MB (CK-MB) and/or an increase in cardiac troponin I (cTnI) or cardiac troponin
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service