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B7148

Sigma-Aldrich

Buspirone hydrochloride

≥99% (TLC), powder, 5-HT1A serotonin receptor agonist

Synonym(s):

N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C21H31N5O2 · HCl
CAS Number:
33386-08-2
Molecular Weight:
421.96
EC Number:
251-489-4
MDL number:
MFCD00078569
UNSPSC Code:
12352200
PubChem Substance ID:
24278079
NACRES:
NA.77

product name

Buspirone hydrochloride,

form

powder

Quality Level

100

originator

Bristol-Myers Squibb

storage temp.

2-8°C

SMILES string

Cl[H].O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4

InChI

1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H

InChI key

RICLFGYGYQXUFH-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350)

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Biochem/physiol Actions

5-HT1A serotonin receptor agonist; anxiolytic.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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G Tunnicliff
Pharmacology & toxicology, 69(3), 149-156 (1991-09-01)
Buspirone has been available in the United States for over four years for the treatment of anxiety. It was anticipated this drug would offer certain advantages over the established benzodiazepines. In contrast to diazepam, early studies found no evidence for
E Meller et al.
Molecular pharmacology, 37(2), 231-237 (1990-02-01)
The irreversible receptor antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) was used to determine the relationship between receptor occupancy and response at central 5-hydroxytryptamine1A (5-HT1A) serotonin receptors mediating the inhibition of serotonin synthesis in rat cortex and hippocampus. Rats were treated with vehicle or
Jan Tack et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 10(11), 1239-1245 (2012-07-21)
Impaired accommodation and hypersensitivity to gastric distention are believed to be involved in the development of functional dyspepsia (FD). Buspirone, a 5-hydroxytryptamine 1A receptor agonist, relaxes the proximal stomach in healthy individuals. We studied the effects of buspirone on symptoms
Sarah J Nicholson et al.
Biopharmaceutics & drug disposition, 33(9), 522-535 (2012-10-16)
Reducing the maximum plasma concentration whilst maintaining the exposure was shown to ameliorate adverse events following the oral administration of 6-hydroxybuspirone. This observation, along with a desire to provide for once daily dosing of this compound, provided the basis for
Hedayat Nazari et al.
Archives of gynecology and obstetrics, 287(3), 469-472 (2012-10-18)
The premenstrual syndrome (PMS), which causes emotional and physical symptoms, is a common problem in many women in their reproductive age. Many approaches to PMS with controversial results are available. The present study was performed to compare fluoxetine and buspirone
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