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Key Documents

AV43994

Sigma-Aldrich

Anti-SLC22A11 (AB1) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-MGC34282, Anti-OAT4, Anti-Solute carrier family 22 (organic anion/urate transporter), member 11, Anti-hOAT4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

60 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_060954

UniProt accession no.

Q9NSA0

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SLC22A11(55867)

Immunogen

Synthetic peptide directed towards the C terminal region of human SLC22A11

Application

Anti-SLC22A11 (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1.0μg/ml.

Biochem/physiol Actions

SLC22A11 (Organic Anion Transporter 4, OAT4) is a membrane protein involved in sodium-dependent transport and excretion of organic anions. This protein is expressed mainly in placenta and in the kidney. A variant of the gene encoding OAT4 has been implicated in the development of a major gout subtype called renal underexcretion type gout.

Sequence

Synthetic peptide located within the following region: ASSLVVLFFLPETQGLPLPDTIQDLESQKSTAAQGNRQEAVTVESTSL

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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James E Shima et al.
American journal of physiology. Renal physiology, 299(4), F767-F775 (2010-07-30)
Apical reabsorption from the urine has been shown to be important for such processes as the maintenance of critical metabolites in the blood and the excretion of nephrotoxic compounds. The solute carrier (SLC) transporter OAT4 (SLC22A11) is expressed on the
Masayuki Sakiyama et al.
Drug metabolism and pharmacokinetics, 29(2), 208-210 (2013-09-13)
Gout, a common disease, is a consequence of hyperuricemia, and increases the risks of hypertension, cardiovascular diseases, cerebrovascular diseases and renal failure. Gout can be classified into 3 types: the renal underexcretion (RUE) type, renal overload type and combined type.

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