A9285
α1-Antichymotrypsin from human plasma
≥92.5% (SDS-PAGE), lyophilized powder
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About This Item
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biological source
human plasma
Quality Level
Assay
≥92.5% (SDS-PAGE)
form
lyophilized powder
mol wt
55-66 kDa
technique(s)
microbiological culture: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... SERPINA3(12)
General description
α1-Antichymotrypsin (α1-ACT) is also known as serpin peptidase inhibitor, clade A member 3 (SERPINA3). It is a 68 kDa serine protease inhibitor, secreted by the liver. It belongs to the serpin superfamily of protease inhibitors. SERPINA3 is located on human chromosome 14q32.1.
Application
α1-Antichymotrypsin from human plasma has been used as a component in yeast extract peptone dextrose broth (YEPD) for biofilm dispersion assays.
Biochem/physiol Actions
α1-Antichymotrypsin (α1-ACT) can block the functions of various serine proteases like chymotrypsin and cathepsin G. It serves as a potential therapeutic target of endometrial carcinoma (EC).
Specific inhibitor of chymotrypsin-like serine proteases. Promotes amyloid-β polymerization in vitro and in vivo. Levels in plasma and cerebrospinal fluid have been found to correlate with progression of dementia in Alzheimer′s patients and induce phosphorylation of tau protein in neurons.
Packaging
Package size based on protein content.
Physical form
Lyophilized powder containing Tris buffer salt and NaCl.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Human plasma proteinase inhibitors.
J Travis et al.
Annual review of biochemistry, 52, 655-709 (1983-01-01)
Up-regulation of SERPINA3 correlates with high mortality of melanoma patients and increased migration and invasion of cancer cells.
Zhou J, et al.
Oncotarget, 8(12), 18712-18712 (2017)
Is Alpha-1 Antichymotrypsin Gene Polymorphism a Risk Factor for Primary Intracerebral Hemorrhage? A Case-Control Study and Meta-Analysis
Hu X, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 2149-2149 (2015)
SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis.
Yang GD
International Journal of Clinical and Experimental Pathology, 7(4), 1348-1358 (2014)
Saliva proteins of vector Culicoides modify structure and infectivity of bluetongue virus particles.
Karin E Darpel et al.
PloS one, 6(3), e17545-e17545 (2011-03-23)
Bluetongue virus (BTV) and epizootic haemorrhagic disease virus (EHDV) are related orbiviruses, transmitted between their ruminant hosts primarily by certain haematophagous midge vectors (Culicoides spp.). The larger of the BTV outer-capsid proteins, 'VP2', can be cleaved by proteases (including trypsin
Articles
Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.
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