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A4034

Sigma-Aldrich

(+)-Sodium L-ascorbate

powder, BioReagent, suitable for cell culture

Synonym(s):

L(+)-Ascorbic acid sodium salt, Vitamin C sodium salt

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About This Item

Empirical Formula (Hill Notation):
C6H7NaO6
CAS Number:
Molecular Weight:
198.11
Beilstein:
3767246
EC Number:
MDL number:
UNSPSC Code:
12352205
eCl@ss:
34058010
PubChem Substance ID:
NACRES:
NA.75

Pricing and availability is not currently available.

biological source

synthetic (organic)

product line

BioReagent

Assay

≥98%

form

powder

mol wt

Mw 135.13 g/mol

technique(s)

cell culture | mammalian: suitable
cell culture | plant: suitable

color

white to off-white

mp

220 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

SMILES string

[Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]

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General description

(+)-Sodium L-ascorbate (SA) is a potential antioxidant and is a derivative of vitamin C (L-ascorbic acid).[1][2] It is widely used as a food additive.[1] In addition, SA enhances growth retardation activity of bleomycin sulfate, R020-1724 (an inhibitor of cyclic nucleotide phosphodiesterase), prostaglandin E1 and sodium butyrate agents on neuroblastoma cells in culture.[3] Elevated levels of SA induces two-stage urinary bladder carcinogenesis in rats.[1] sodium L-ascorbate in combination with collagenogenesis inhibitors is used to treat dermal scars and keloids.[2]

Application

(+)-Sodium L-ascorbate has been used:
  • to produce H2O2 in cell culture media[4][5]
  • as a reducing agent for a cell-permeable artificial electron donor, N,N,N′,N′-tetramethyl-p-phenylenediamine (TMPD)[6]
  • to study its effect on production of collagen and elastic fibers in fibroblasts cultures derived from normal human skin and dermal fat[2]

Used for preparation of plant extracts; reductant for the isolation of chloroplasts.

Biochem/physiol Actions

Antioxidant

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Sodium ascorbate potentiates the growth inhibitory effect of certain agents on neuroblastoma cells in culture
    Prasad KN, et al.
    Proceedings of the National Academy of Sciences of the USA, 76(2), 829-832 (1979)
    Promoting effects of sodium L-ascorbate on two-stage urinary bladder carcinogenesis in rats
    Fukushima S, et al.
    Cancer Research, 43(9), 4454-4457 (1983)
    Artefacts in cell culture: pyruvate as a scavenger of hydrogen peroxide generated by ascorbate or epigallocatechin gallate in cell culture media
    Long LH and Halliwell B
    Biochemical and Biophysical Research Communications, 388(4), 700-704 (2009)
    The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species
    Bordt EA, et al.
    Developmental Cell, 40(6), 583-594 (2017)
    Artefacts in cell culture: alpha-Ketoglutarate can scavenge hydrogen peroxide generated by ascorbate and epigallocatechin gallate in cell culture media
    Long LH and Halliwell B
    Biochemical and Biophysical Research Communications, 406(1), 20-24 (2011)

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