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A254

Sigma-Aldrich

AIDA

solid

Synonym(s):

1-Amino-2,3-dihydro-1H-indene-1,5-dicarboxylic acid, 1-Aminoindan-1, 5-dicarboxylic acid, UPF 523

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About This Item

Empirical Formula (Hill Notation):
C11H11NO4
CAS Number:
168560-79-0
Molecular Weight:
221.21
MDL number:
MFCD00672638
UNSPSC Code:
12352200
PubChem Substance ID:
24277957
NACRES:
NA.32

form

solid

Quality Level

100

color

white

solubility

DMSO: 2 mg/mL

SMILES string

NC1(CCc2cc(ccc12)C(O)=O)C(O)=O

InChI

1S/C11H11NO4/c12-11(10(15)16)4-3-6-5-7(9(13)14)1-2-8(6)11/h1-2,5H,3-4,12H2,(H,13,14)(H,15,16)

InChI key

LSTPKMWNRWCNLS-UHFFFAOYSA-N

Gene Information

human ... GRM1(2911)
rat ... Grm1(24414)

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Biochem/physiol Actions

Selective mGluR1 metabotropic glutamate receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Andreas Schuster et al.
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Background: Right ventricular (RV) function is a known predictor of adverse events in heart failure and following acute myocardial infarction (AMI). While right atrial (RA) involvement is well characterized in pulmonary arterial hypertension, its relative contributions to adverse events following
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Molecular neurodegeneration, 12(1), 88-88 (2017-12-06)
The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggregation and pronounced neuronal loss in the hippocampus whereas the anti-aggregant
Friedrich-Christian Deuschle et al.
Theranostics, 10(5), 2172-2187 (2020-02-25)
Enhanced amino acid supply and dysregulated integrin signaling constitute two hallmarks of cancer and are pivotal for metastatic transformation of cells. In line with its function at the crossroads of both processes, overexpression of CD98hc is clinically observed in various
F Moroni et al.
The Journal of pharmacology and experimental therapeutics, 281(2), 721-729 (1997-05-01)
We examined the pharmacological profile of 1-aminoindan-1,5-dicarboxylic acid (AIDA), a rigid (carboxyphenyl)glycine derivative acting on metabotropic glutamate receptors (mGluRs). In cells transfected with mGluR1a, AIDA competitively antagonized the stimulatory responses of glutamate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD] on phosphoinositide hydrolysis (pA2
Federico Brandalise et al.
PloS one, 7(8), e43417-e43417 (2012-09-01)
In the cerebellar glomerulus, GABAergic synapses formed by Golgi cells regulate excitatory transmission from mossy fibers to granule cells through feed-forward and feedback mechanisms. In acute cerebellar slices, we found that stimulating Golgi cell axons with a train of 10
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