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78544

Sigma-Aldrich

Glucose tetrasaccharide

≥99.0% (TLC)

Synonym(s):

Glcα1-6Glcα1-4Glcα1-4Glc

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About This Item

Empirical Formula (Hill Notation):
C24H42O21
CAS Number:
35175-16-7
Molecular Weight:
666.58
MDL number:
MFCD09840666
UNSPSC Code:
12352201
PubChem Substance ID:
329768157
NACRES:
NA.28

Quality Level

100

Assay

≥99.0% (TLC)

form

powder

color

white

suitability

corresponds for LC-MS

storage temp.

room temp

SMILES string

OC[C@H]1O[C@H](OC[C@H]2O[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3CO)O[C@H]4[C@H](O)[C@@H](O)C(O)O[C@@H]4CO)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C24H42O21/c25-1-5-9(28)11(30)16(35)22(41-5)39-4-8-10(29)12(31)17(36)23(43-8)45-20-7(3-27)42-24(18(37)14(20)33)44-19-6(2-26)40-21(38)15(34)13(19)32/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10-,11+,12+,13-,14-,15-,16-,17-,18-,19-,20-,21?,22+,23-,24-/m1/s1

InChI key

FPBCRLIOSBQLHS-QVTSYAGHSA-N

Application

Glucose tetrasaccharide (Glc4) is used as a reference in analysis of urinary glucose tetrasacchaide, a biomarker for Pompe disease and other glycogen storage diseases.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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W T Wang et al.
Analytical biochemistry, 182(1), 48-53 (1989-10-01)
In the present work we have explored conditions for using a pulsed amperometric detector for on-line analysis of oligosaccharides eluted from a high-performance liquid affinity chromatography column. A monoclonal antibody that specifically binds a glucose-containing oligosaccharide is coupled to a
Victoria Manwaring et al.
Journal of inherited metabolic disease, 35(2), 311-316 (2011-06-21)
A high performance liquid chromatography method, adapted from an established urinary sugars method, has been developed for the analysis of a tetraglucose oligomer (Glc(4)) in urine. Pompe disease results from defects in the activity of lysosomal acid α-glucosidase (GAA) with
Yoav H Messinger et al.
Genetics in medicine : official journal of the American College of Medical Genetics, 14(1), 135-142 (2012-01-13)
Infantile Pompe disease resulting from a deficiency of lysosomal acid α-glucosidase (GAA) requires enzyme replacement therapy (ERT) with recombinant human GAA (rhGAA). Cross-reactive immunologic material negative (CRIM-negative) Pompe patients develop high-titer antibody to the rhGAA and do poorly. We describe
Yin-Hsiu Chien et al.
Molecular genetics and metabolism reports, 23, 100591-100591 (2020-05-07)
Enzyme replacement therapy (ERT), the only approved therapy for infantile-onset Pompe disease (IOPD), had heterogeneous clinical effects due to factors such as severity, age at first treatment, dosage, and dosing regimens. We report the clinical and biochemical outcomes of a
Unique oligosaccharide (apparently glucotetrasaccharide) in urine of patients with glycogen storage diseases.
K Oberholzer et al.
Clinical chemistry, 36(7), 1381-1381 (1990-07-01)
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