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74480

Sigma-Aldrich

L-Norepinephrine hydrochloride

≥98.0% (sum of enantiomers, HPLC)

Synonym(s):

L-Arterenol hydrochloride, L-Noradrenaline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C8H11NO3 · HCl
CAS Number:
329-56-6
Molecular Weight:
205.64
Beilstein:
3916100
EC Number:
206-345-5
MDL number:
MFCD00064560
UNSPSC Code:
12352209
PubChem Substance ID:
57652452
NACRES:
NA.77

Assay

≥98.0% (sum of enantiomers, HPLC)

form

crystals

optical activity

[α]20/D −38.5±5°, c = 2% in H2O

mp

~150 °C (dec.)

storage temp.

2-8°C

SMILES string

Cl[H].NC[C@H](O)c1ccc(O)c(O)c1

InChI

1S/C8H11NO3.ClH/c9-4-8(12)5-1-2-6(10)7(11)3-5;/h1-3,8,10-12H,4,9H2;1H/t8-;/m0./s1

InChI key

FQTFHMSZCSUVEU-QRPNPIFTSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)

Biochem/physiol Actions

Adrenal medullary stress hormone, mediator of the fight-or-flight response; and the primary neurotransmitter in the post-ganglionic sympathetic (adrenergic) nervous system.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300 + H310 + H330

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hypertension (Dallas, Tex. : 1979), 64(1), 178-184 (2014-05-07)
Excessive renal efferent sympathetic nerve activity contributes to hypertension in many circumstances. Although both hemodynamic and tubular effects likely participate, most evidence supports a major role for α-adrenergic receptors in mediating the direct epithelial stimulation of sodium retention. Recently, it
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The Laryngoscope, 124(5), E188-E193 (2013-10-12)
Noise generated by instruments, such as mastoid or craniotomy drills, may cause hearing damage by reducing the cochlear blood flow (CoBF). This study investigated whether dexmedetomidine can lessen noise-induced hearing loss (NIHL) in a guinea pig model. Animal study using
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The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(1), 36-50 (2014-01-02)
Neuronal networks are endogenously modulated by aminergic and peptidergic substances. These modulatory processes are critical for maintaining normal activity and adapting networks to changes in metabolic, behavioral, and environmental conditions. However, disturbances in neuromodulation have also been associated with pathologies.
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