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Key Documents

45299

Sigma-Aldrich

Epoxide Hydrolase from Rhodococcus rhodochrous

lyophilized powder, beige, ≥0.2 U/g

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About This Item

CAS Number:
Enzyme Commission number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54

form

lyophilized powder

Quality Level

specific activity

≥0.2 U/g

color

beige

storage temp.

2-8°C

Biochem/physiol Actions

Epoxide hydrolase is an enantioselective catalyst for the hydrolytic kinetic resolution of epoxides.

Unit Definition

1 U corresponds to the amount of enzymes which hydrolizes 1 μmol (S)-NEPC [(2S,3S)-trans-3-phenyl-2-oxiranylmethyl-4-nitrophenyl carbonate, Prod. No. 04088] per minute at pH 8.0 and 25 °C

Other Notes

Asymmetric hydrolysis of epoxides to optically active diols

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Resp. Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hechtberger, P.
Tetrahedron Asymmetry, 4, 1161-1161 (1993)
Mischitz, M., et al.
Tetrahedron Asymmetry, 7, 2041-2041 (1996)
E N Jacobsen
Accounts of chemical research, 33(6), 421-431 (2000-07-13)
The discovery of the metal salen-catalyzed asymmetric ring-opening (ARO) of epoxides is chronicled. A screening approach was adopted for the identification of catalysts for the addition of TMSN(3) to meso-epoxides, and the chiral (salen)CrN(3) complex was identified as optimal. Kinetic
Ana W Y Cheong et al.
Biology of reproduction, 81(1), 126-132 (2009-03-27)
Somatic cell-embryo coculture enhances embryo development in vitro by producing embryotrophic factor(s) and/or removing harmful substances from the culture environment. Yet, the underlying molecular mechanisms on how somatic cells remove the toxicants from the culture medium remain largely unknown. By
Zhuo Shao et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(3), 581-586 (2014-01-25)
Regulation of angiogenesis is critical for many diseases. Specifically, pathological retinal neovascularization, a major cause of blindness, is suppressed with dietary ω3-long-chain polyunsaturated fatty acids (ω3LCPUFAs) through antiangiogenic metabolites of cyclooxygenase and lipoxygenase. Cytochrome P450 epoxygenases (CYP2C8) also metabolize LCPUFAs

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