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P3800000

Proxyphylline

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

7-(β-Hydroxypropyl)theophylline, (1,3-Dimethyl-7-[2-hydroxypropyl]-2,6-dioxopurine), Proxyphylline

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About This Item

Empirical Formula (Hill Notation):
C10H14N4O3
CAS Number:
603-00-9
Molecular Weight:
238.24
MDL number:
MFCD00022833
UNSPSC Code:
41116107
PubChem Substance ID:
329820192
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

proxyphylline

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(O)Cn1cnc2N(C)C(=O)N(C)C(=O)c12

InChI

1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3

InChI key

KYHQZNGJUGFTGR-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Proxyphylline EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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M V Badiger et al.
Biomaterials, 14(14), 1059-1063 (1993-11-01)
To enable the synthesis of hydrogels containing microporosity, a family of pore generating additives (porogens) were synthesized from poly(ethylene glycols) (PEGs) with different molecular weights using naphthyl acetic acid. The products formed were characterized by UV-vis, differential scanning calorimetry and
Dimitrios N Soulas et al.
International journal of pharmaceutics, 427(2), 192-200 (2012-02-15)
In this work we present results on the release kinetics of a water-soluble model drug (proxyphylline) from symmetrical three-layer ABA matrices made from silicone rubber. The ABA matrices, consisting of an inner drug-containing layer, loaded at concentration near the percolation
A R Khare et al.
Journal of biomaterials science. Polymer edition, 4(3), 275-289 (1993-01-01)
Controlled release systems of theophylline, proxyphylline and oxprenolol.HCl exhibiting modulated drug delivery were prepared by using pH-sensitive anionic copolymers of 2-hydroxyethyl methacrylate with acrylic acid or methacrylic acid. Drug release studies were carried out in simulated biological fluids. The initial
D Agbaba et al.
Biomedical chromatography : BMC, 6(3), 141-142 (1992-05-01)
The content and dissolution rate of theophylline, diprophylline and proxyphylline from a sustained release formulation were determined by UV in situ densitometry. After separation the chromatographic zones corresponding to the spots of theophylline, diprophylline and proxyphylline on the high performance
A M Lowman et al.
Journal of biomaterials science. Polymer edition, 10(9), 999-1009 (1999-11-26)
We report on the preparation and properties of hydrogels of poly(methacrylic acid-g-ethylene glycol) that exhibit pH-responsive swelling behavior due to the reversible formation/dissociation of interpolymer complexes. Because of their nature, these materials may be useful in drug delivery applications. In
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