Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

I0020000

Ibuprofen

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propanoic acid

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C13H18O2
CAS Number:
15687-27-1
Molecular Weight:
206.28
MDL number:
MFCD00010393
UNSPSC Code:
41116107
PubChem Substance ID:
329815293
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

ibuprofen

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(C)Cc1ccc(cc1)C(C)C(O)=O

InChI

1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

InChI key

HEFNNWSXXWATRW-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

Looking for similar products? Visit Product Comparison Guide

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ibuprofen EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

PHR1146

Ibuprofen Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

1335508

Ibuprofen, United States Pharmacopeia (USP) Reference Standard

1335541

Ibuprofen Related Compound C, United States Pharmacopeia (USP) Reference Standard

B1220000

Ibuprofen impurity B, European Pharmacopoeia (EP) Reference Standard

Y0000140

Ibuprofen impurity F, European Pharmacopoeia (EP) Reference Standard

Y0000881

Ibuprofen for peak identification, European Pharmacopoeia (EP) Reference Standard

61849

2-[4-(2-Methylpropyl)phenyl]ethanol, pharmaceutical impurity standard

1335596

Ibuprofen Related Compound J, United States Pharmacopeia (USP) Reference Standard

PHR1934

Ibuprofen Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1964

Ibuprofen Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1933

Ibuprofen Impurity A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1935

Ibuprofen Impurity N, Pharmaceutical Secondary Standard; Certified Reference Material

BP539

Ibuprofen, British Pharmacopoeia (BP) Reference Standard

BP557

4′-Isobutylacetophenone, British Pharmacopoeia (BP) Reference Standard

PHR2028

Ibuprofen Impurity H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1965

Ibuprofen Impurity G, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2122

2-(4-Isobutyrylphenyl)propanamide, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2146

2-(4-Isobutylphenyl)-N-(1-phenylethyl)propionamide, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2141

2-(4-Isobutylphenyl)prop-2-enoic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2136

4-(1-Hydroxy-2-methylpropyl)-acetophenone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2143

Ibuprofen 2,3-Butylene Glycol Ester, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2142

Ibuprofen 1,3-Butylene Glycol Esters, Pharmaceutical Secondary Standard; Certified Reference Material

BP880

Ibuprofen impurity B, British Pharmacopoeia (BP) Reference Standard

PHR2124

4-Isobutyrylacetophenone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2145

Ibuprofen 1,2-Propanetriol Esters, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2144

Ibuprofen 1,2-Propylene Glycol Esters, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2483

4-Acetylbenzoic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2138

Ibuprofen Ethyl Ester

PHR2125

2-(4-Isobutyrylphenyl)propane

PHR2127

2-(4-n-Propylphenyl)propanoic Acid

PHR2129

Isopropyl 2-(4-Isobutylphenyl)propanoate

PHR2130

1-Ethyl-4-isobutylbenzene

PHR2134

4-Isobutylstyrene

PHR2135

1-(4-Isobutylphenyl)ethanol

PHR2132

2-[4-(2-Hydroxy-2-methylpropyl)-phenyl]propanoic Acid, certified reference material, pharmaceutical secondary standard

PHR2137

Ibuprofen Methyl Ester, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2133

Ibuprofen Intermediate, certified reference material, pharmaceutical secondary standard

PHR2126

2-Hydroxypropyl 2-(4-Isobutylphenyl)-propanoate, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2269

4-Isobutylbenzoic acid, Pharmaceutical Secondary Standard; Certified Reference Material

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

R O Day et al.
Clinical pharmacology and therapeutics, 43(5), 480-487 (1988-05-01)
The simultaneous disposition of the enantiomers of ibuprofen in synovial fluid and plasma was studied in eight patients with arthritis. Concentrations of the active S-enantiomer in synovial fluid exceeded those of the R-enantiomer at all times in all patients with
J B Whitlam et al.
Clinical pharmacology and therapeutics, 29(4), 487-492 (1981-04-01)
Free and total ibuprofen levels in serum and synovial fluid (SF) were determined in one male and 14 female arthritic patients (mean age 56 yr, range 19 to 77) after 400 mg three times daily for 2 days. Free drug
Sheena Derry et al.
The Cochrane database of systematic reviews, 10(10), CD007550-CD007550 (2013-10-24)
This review is an update of a previously published review in The Cochrane Database of Systematic Reviews Issue 3, 2009 on single dose oral dexibuprofen (S(+)-ibuprofen) for acute postoperative pain in adults.Dexibuprofen is a non-steroidal anti-inflammatory drug (NSAID) licensed for
Roland Neumann et al.
Neonatology, 102(1), 9-15 (2012-03-15)
Pharmacological closure of patent ductus arteriosus (PDA) is commonly achieved by intravenous (IV) administration of ibuprofen or indomethacin. Occasionally, oral ibuprofen is used for PDA treatment although its efficacy and safety are unclear. To systematically review randomized and quasi-randomized trials
James F Markworth et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(11), R1281-R1296 (2013-10-04)
Classical proinflammatory eicosanoids, and more recently discovered lipid mediators with anti-inflammatory and proresolving bioactivity, exert a complex role in the initiation, control, and resolution of inflammation. Using a targeted lipidomics approach, we investigated circulating lipid mediator responses to resistance exercise
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service