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Key Documents

E2499900

Etofenamate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid 2-(2-hydroxyethoxy)ethyl ester

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About This Item

Empirical Formula (Hill Notation):
C18H18F3NO4
CAS Number:
30544-47-9
Molecular Weight:
369.34
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

etofenamate

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

InChI

1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2

InChI key

XILVEPYQJIOVNB-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Etofenamate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H301,H410

Precautionary Statements

P301 + P330 + P331 + P310

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

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Yalcin Golcuk et al.
Clinical toxicology (Philadelphia, Pa.), 48(5), 471-472 (2010-07-01)
Toxic epidermal necrolysis (Lyell syndrome) is a rare, acute, and potentially life-threatening mucocutaneous disease that is most often triggered by drugs. This is the first case of toxic epidermal necrolysis because of treatment with etofenamate of which we are aware.
José Luis Acosta Patiñio et al.
Acta ortopedica mexicana, 21(5), 253-255 (2007-12-28)
To demonstrate that the application of etofenamate is effective in management of acute pain. We conducted a prospective, longitudnal, 6 months trial, which included 22 women and 18 men with intense acute low back pain of mechanical or postural aetiology
Contact dermatitis from etofenamate.
A Götze et al.
Contact dermatitis, 26(3), 209-209 (1992-03-01)
Uriah Guevara-López et al.
Cirugia y cirujanos, 72(6), 483-490 (2005-02-08)
The analgesic efficacy of intramuscular etofenamate (1 g/day) and intramuscular diclofenac (75 mg/day) was assessed in post-surgical pain relief during a period of 3 days. One hundred ten hospitalized patients undergoing elective surgery were evaluated in an open-label, comparative, randomized
G Köhler et al.
Arzneimittel-Forschung, 42(12), 1487-1491 (1992-12-01)
Studies on Plasma and Tissue Concentrations of Etofenamate following Intramuscular Application/Pharmacokinetics of etofenamate and flutenamic acid in plasma, synovia and tissues of patients with chronic polyarthritis after application of oily etofenamat solution Pharmacokinetics of etofenamate (ETO, CAS 30544-47-9; Rheumon i.m.)
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