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Key Documents

D2963000

Doxapram hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Doxapram hydrochloride monohydrate, 1-Ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone monohydrochloride monohydrate

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About This Item

Empirical Formula (Hill Notation):
C24H30N2O2 · HCl · H2O
CAS Number:
7081-53-0
Molecular Weight:
432.98
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

doxapram

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

InChI

1S/C24H30N2O2.ClH.H2O/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21;;/h3-12,22H,2,13-19H2,1H3;1H;1H2

InChI key

ZOMBFZRWMLIDPX-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Doxapram hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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U Bleul et al.
Theriogenology, 73(5), 612-619 (2009-12-22)
Respiratory stimulants are widely used in asphyxic neonatal calves despite a lack of data about their effectiveness and indications of possible side effects. The effect of doxapram and theophylline on respiratory, cardiovascular, and acid-base variables was investigated in 10 healthy
A Greenough et al.
Archives of disease in childhood. Fetal and neonatal edition, 93(3), F242-F245 (2007-11-17)
Randomised trials have demonstrated that ventilation techniques which support every spontaneous breath are the most efficacious weaning modes. Nasal continuous positive airway pressure after extubation reduces the likelihood of incidents leading to the need for reintubation in very low birthweight
Advantages of doxapram for post-anaesthesia recovery and outcomes in bariatric surgery patients with obstructive sleep apnoea.
Olumuyiwa A Bamgbade
European journal of anaesthesiology, 28(5), 387-388 (2010-12-31)
J Manens et al.
Veterinary journal (London, England : 1997), 193(1), 217-221 (2011-11-22)
The present study investigated the effects of bodyweight (BW) gain on respiratory function and airway responsiveness in healthy Beagles using barometric whole body plethysmography (BWBP). Six adult dogs were examined before and after a fattening diet. The high-energy diet induced
Doxapram revisited in patients with cancer.
Eric Li et al.
Journal of palliative medicine, 12(8), 673-673 (2009-08-12)
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