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C1950000

Chlorthalidone

European Pharmacopoeia (EP) Reference Standard

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About This Item

Empirical Formula (Hill Notation):
C14H11ClN2O4S
CAS Number:
77-36-1
Molecular Weight:
338.77
MDL number:
MFCD00036257
UNSPSC Code:
41116107
PubChem Substance ID:
329774919
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

chlorthalidone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

NS(=O)(=O)c1cc(ccc1Cl)C2(O)NC(=O)c3ccccc23

InChI

1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)

InChI key

JIVPVXMEBJLZRO-UHFFFAOYSA-N

Gene Information

human ... SLC12A3(6559)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Chlorthalidone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Edarbyclor: an ARB/chlorthalidone combination for hypertension.
The Medical letter on drugs and therapeutics, 54(1385), 17-18 (2012-03-03)
Are chlorthalidone and hydrochlorothiazide equivalent blood-pressure-lowering medications?
Nitin Khosla et al.
Journal of clinical hypertension (Greenwich, Conn.), 7(6), 354-356 (2005-08-10)
[Importance of the continuity of anti-hypertension treatment in prevention of ischemic cardiovascular diseases: preliminary note. Controlled study of hypertensive patients treated with amiloride associated with hydrochlorothiazide and chlorthalidone].
C de Pasquale et al.
Minerva medica, 69(31), 2115-2123 (1978-06-23)
James R Singer et al.
Journal of glaucoma, 24(1), 84-86 (2014-01-23)
To report a novel case of acute bilateral uveal effusions, angle closure, and acute myopia induced by administration of chlorthalidone. Case report. Bilateral shallow anterior chambers, high intraocular pressure, and a myopic shift were encountered in a patient 1 week
George C Roush et al.
Current hypertension reports, 15(5), 514-521 (2013-07-11)
How chlorthalidone (CTDN) reduces risk for cardiovascular events (CVEs) can be considered in light of its ability to lower blood pressure (BP) and its non-BP related, pleiotropic effects. The mechanism by which CTDN lowers BP is unclear but may include
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