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Cefuroxime

VETRANAL®, analytical standard

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About This Item

Empirical Formula (Hill Notation):
C16H16N4O8S
CAS Number:
Molecular Weight:
424.39
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@H]2NC(=O)\C(=N/OC)c3ccco3)C(O)=O

InChI

1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1

InChI key

JFPVXVDWJQMJEE-IZRZKJBUSA-N

General description

Cefuroxime is a new broad-spectrum cephalosporin antibiotic, with increased stability to β-lactamases. It is actively used against gram-positive organisms, including penicillinase-producing staphylococci and non-β-lactamase-producing gram-negative bacteria.
Chemical structure: ß-lactam

Application

Cefuroxime may be used as a reference standard in the determination of cefuroxime in plasma samples using high-performance liquid chromatography (HPLC).(3)
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Simon Farnebo et al.
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Dandan He et al.
Antimicrobial agents and chemotherapy, 60(10), 6084-6090 (2016-08-03)
Clinical isolates producing hybrid CTX-M β-lactamases, presumably due to recombination between the blaCTX-M-15 and blaCTX-M-14 elements, have emerged in recent years. Among the hybrid enzymes, CTX-M-64 and CTX-M-14 display the most significant difference in catalytic activity. This study aims to
Cefuroxime, a new cephalosporin antibiotic: activity in vitro.
O'Callaghan HC, et al.
Antimicrobial Agents and Chemotherapy, 9(3), 511-519 (1976)
Grigorios Tsigkas et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 39(12), 840-847 (2016-06-24)
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Dorothea Leonhäuser et al.
Journal of translational medicine, 15(1), 3-3 (2017-01-05)
The repair of urinary bladder tissue is a necessity for tissue loss due to cancer, trauma, or congenital abnormalities. Use of intestinal tissue is still the gold standard in the urological clinic, which leads to new problems and dysfunctions like

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