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230987

Sigma-Aldrich

Victoria Pure Blue BO

Dye content 90 %

Synonym(s):

Basic Blue 7

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About This Item

Empirical Formula (Hill Notation):
C33H40ClN3
CAS Number:
2390-60-5
Molecular Weight:
514.14
Colour Index Number:
42595
EC Number:
219-232-0
MDL number:
MFCD00011877
UNSPSC Code:
12171500
PubChem Substance ID:
24853845
NACRES:
NA.47

form

powder, crystals or chunks

Quality Level

100

composition

Dye content, 90%

solubility

95% ethanol: 0.1%, blue to very deep blue

λmax

619 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Cl-].CCNc1ccc(\C(c2ccc(cc2)N(CC)CC)=C3/C=C\C(C=C3)=[N+](\CC)CC)c4ccccc14

InChI

1S/C33H39N3.ClH/c1-6-34-32-24-23-31(29-13-11-12-14-30(29)32)33(25-15-19-27(20-16-25)35(7-2)8-3)26-17-21-28(22-18-26)36(9-4)10-5;/h11-24H,6-10H2,1-5H3;1H

InChI key

ROVRRJSRRSGUOL-UHFFFAOYSA-N

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General description

Victoria blue dyes are triaminodiphenylnaphthylmethanes, with lipophilic cations and large conjugated systems.

Signal Word

Danger

Hazard Statements

H301,H318,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SHBM2410
MKCH0861
MKBK5906V
MKBL8015V
MKBK1928V

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A Viola et al.
International journal of cancer, 85(5), 733-739 (2000-03-04)
Victoria Blue BO (VB BO) is a new and promising photosensitizer currently being evaluated for photodynamic therapy (PDT). Its photochemical processes are mediated by oxygen radicals, but do not involve singlet oxygen. We used (31)P NMR spectroscopy of VB-BO sensitized
Zong Jie Cui et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 1(12), 1001-1005 (2003-03-29)
The adrenergic agonist phenylephrine (PE) induced typical [Ca2+]i oscillations in freshly isolated rat hepatocytes, and the photodynamic effect of Victoria Blue BO on induced calcium oscillations was investigated. PE induced calcium oscillations disappeared after Victoria Blue BO photodynamic action (in
A Viola et al.
Journal of photochemistry and photobiology. B, Biology, 32(1-2), 49-58 (1996-01-01)
Electron paramagnetic resonance (EPR) experiments were performed on Victoria Blue BO, a cationic dye whose photocytotoxicity has been studied against the human leukaemic cell lines K-562 and TF-1. EPR experiments with 2,2,6,6-tetramethyl-4-piperidone and spin trapping with 5,5-dimethyl-1-pyrroline-N-oxide showed that, on
J Morgan et al.
Photochemistry and photobiology, 67(1), 155-164 (1998-04-04)
The cationic photosensitizing triaryl methane dye Victoria Blue BO (VBBO) localizes in mitochondria and causes oxidative damage to this organelle during photodynamic therapy (PDT). Oxidative stresses from other photosensitizers induce a variety of stress proteins. The endoplasmic reticulum (ER)-based, calcium-binding
S M Burrow et al.
Membrane & cell biology, 14(3), 357-366 (2001-05-23)
Victoria Blue BO (VBBO) is thought to exert its photocytotoxic effects via free radical generation. Glutathione and related enzymes are associated with the protection of normal tissues against free-radical damage and have also been implicated in multiple drug resistance. It
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