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Key Documents

MAB3307

Sigma-Aldrich

Anti-MMP-1 Antibody, a.a. 332-350 hMMP1, clone 41-1E5

clone 41-1E5, Chemicon®, from mouse

Synonym(s):

Fibroblast Collagenase, Interstitial Collagenase

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

41-1E5, monoclonal

species reactivity

rabbit, human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NM_002421.2

UniProt accession no.

P03956

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... MMP1(4312)

Specificity

Specifically reacts with precursor and active forms of human MMP-1.

Immunogen

Epitope: a.a. 332-350 hMMP1
Syntheic peptide aa332-350 of hMMP-1

Application

Anti-MMP-1 Antibody, a.a. 332-350 hMMP1, clone 41-1E5 detects level of MMP-1 & has been published & validated for use in ELISA, IH(P) & WB.
Immunoblotting:

Immunohistochemistry on PLP fixed, paraffin-embedded tissues 5-20μg/ml. PLP fixation required for best results. Antibody also reacts with frozen tissues. Reactivity on tradional formalin fixed tissue is poor. Microwave antigen retrieval is recommended

ElA

Target description

52 kDa

Linkage

Replaces: 04-1122

Physical form

Format: Purified
Liquid in 0.1 M Na-Phosphate buffer, pH 7.0 containing 2% protease free bovine Serum albumin.

Analysis Note

Control
Cervical carcinoma

SKBr-3 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Carine Strup-Perrot et al.
World journal of gastroenterology, 11(40), 6312-6321 (2006-01-19)
To investigate their expression and activity in the rat ileum after exposure to ionizing radiation along with that of the cellular effectors and molecular mediators involved in the regulation of MMPs. Rats were exposed to a single 10-Gy dose of
Angela Ghatnekar et al.
The American journal of pathology, 182(6), 2391-2406 (2013-04-16)
Pulmonary arterial hypertension (PAH) is a chronic and progressive disease characterized by pulmonary vasculopathy with elevation of pulmonary artery pressure, often culminating in right ventricular failure. GATA-6, a member of the GATA family of zinc-finger transcription factors, is highly expressed
Satoru Kondo et al.
International journal of cancer, 115(3), 368-376 (2005-02-03)
The Epstein-Barr Virus (EBV) latent membrane protein 1 (LMP1) has a significant role in several malignancies, including nasopharyngeal carcinoma (NPC). LMP1 is the principal oncoprotein, and we have shown that it also induces a set of factors that mediates invasion
A B Frey et al.
Histopathology, 50(6), 720-726 (2007-05-12)
Osteopontin (OPN) is a matricellular protein involved in tissue remodelling, cell-mediated immunity and malignant transformation. High OPN serum levels predict poor prognosis in non-small cell carcinoma and set patients with malignant pleural mesothelioma (MM) apart from disease-free asbestos-exposed individuals. Yet
Marc Irqsusi et al.
Journal of cardiac surgery, 37(6), 1613-1622 (2022-03-29)
The pathogenesis of mitral valve insufficiency is not yet fully understood. Several studies stressed the role of matrix metalloproteinases (MMPs) in the emergence of valvular pathologies. The primary objective of the present study is to analyze the role of selected MMPs
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