MAB3306
Anti-MMP-3 Antibody, cross reacts w/hMMP-10, clone 55-2A4
clone 55-2A4, Chemicon®, from mouse
Synonym(s):
Stromelysin-1, Transin, Proteoglycanase
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
55-2A4, monoclonal
species reactivity
human, pig, rat, sheep
should not react with
bovine, rabbit, mouse
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... MMP3(4314)
Specificity
The antibody specifically reacts with precursor and active forms of human MMP-3. This is a purified mouse monoclonal antibody to human matrix metalloproteinase 3 (human MMP-3, stromelysin-1) from synovial cells. The antibody cross reacts 34% with human MMP-10.
Immunogen
Epitope: cross reacts w/hMMP-10
Human matrix metalloproteinase 3 (human MMP-3, stromelysin-1) from synovial cells.
Application
Immunoblotting (0.5 μg/mL)
Immunohistochemistry on paraffin-embedded tissues (5-10μg/mL, PLP fixation required, not recommended for traditional formalin fixation. Immunohistochemistry on fresh frozen sections (0.5 μg/mL)
ElA
Immunohistochemistry on paraffin-embedded tissues (5-10μg/mL, PLP fixation required, not recommended for traditional formalin fixation. Immunohistochemistry on fresh frozen sections (0.5 μg/mL)
ElA
Research Category
Cell Structure
Cell Structure
Research Sub Category
MMPs & TIMPs
MMPs & TIMPs
This Anti-MMP-3 Antibody, cross reacts w/hMMP-10, clone 55-2A4 is validated for use in ELISA, WB, IH(P) for the detection of MMP-3.
Physical form
Format: Purified
Liquid in 0.01M Na-Phosphate buffer, pH 7.0, 125 mM NaCl, containing 2% protease free bovine serum albumin.
Storage and Stability
Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Manufactured by Daiichi Fine Chemical Co., Ltd
Manufactured by Daiichi Fine Chemical Co., Ltd
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Kalu U E Ogbureke et al.
Kidney international, 68(1), 155-166 (2005-06-16)
Three members of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins have recently been shown to bind and activate specific promatrix metalloproteinases (MMPs) and to overcome the inhibition of tissue inhibitors of MMPs (TIMPs). Although usually associated with
Tracy N Clevenger et al.
Journal of tissue engineering, 7, 2041731416670482-2041731416670482 (2016-10-14)
One of the most common regenerative therapies is autologous fat grafting, which frequently suffers from unexpected volume loss. One approach is to deliver adipose stem cells encapsulated in the engineered hydrogels supportive of cell survival, differentiation, and integration after transplant.
Iraklis Papageorgiou et al.
Nanomaterials (Basel, Switzerland), 4(2), 485-504 (2014-06-16)
Medical interventions for the treatment of spinal disc degeneration include total disc replacement and fusion devices. There are, however, concerns regarding the generation of wear particles by these devices, the majority of which are in the nanometre sized range with
Allison L Arai et al.
Biochemistry, 59(32), 2922-2933 (2020-07-24)
Matrix metalloprotease (MMP) activation contributes to the degradation of the extracellular matrix (ECM), resulting in a multitude of pathologies. Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifaceted endocytic and signaling receptor that is responsible for internalization and lysosomal degradation
M Fréchet et al.
Oncogene, 27(39), 5223-5232 (2008-05-13)
Xeroderma pigmentosum (XP) is a rare, recessively inherited genetic disease characterized by skin cancer proneness and premature aging in photoexposed area. The disease results from defective nucleotide excision repair of ultraviolet (UV)-induced DNA lesions. Reconstruction of group C (XP-C) skin
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