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MAB1920

Sigma-Aldrich

Anti-Laminin γ1 Antibody, clone 2E8

ascites fluid, clone 2E8, Chemicon®

Synonym(s):

Laminin B2 Chain

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

ascites fluid

antibody product type

primary antibodies

clone

2E8, monoclonal

species reactivity

rat, human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
cell culture | mammalian: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_002293.3

UniProt accession no.

P11047

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... LAMC1(3915)

Specificity

Reacts with the B2 chain of intact human laminin and does not block the neurite stimulating activity of laminin. Cross reacts with the 200 kDa chain of rat laminin.

Application

ELISA (50% maximal binding to human laminin): (1:300,000.

Immunofluorescence

Affinity chromatography

Immunoprecipitation

Immunoblotting

Optimal working dilutions must be determined by end user.
This Anti-Laminin γ1 Antibody, clone 2E8 is validated for use in ELISA, CULT, IH, IP, WB for the detection of Laminin γ1.

Target description

200 kDa

Physical form

Liquid, no preservatives added.

Analysis Note

Control
Basement membrane, Hippocampal tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Steven D Funk et al.
Journal of the American Society of Nephrology : JASN, 29(3), 949-960 (2017-12-22)
Pierson syndrome is a congenital nephrotic syndrome with eye and neurologic defects caused by mutations in laminin β2 (LAMB2), a major component of the glomerular basement membrane (GBM). Pathogenic missense mutations in human LAMB2 cluster in or near the laminin
Treadmill exercise induced functional recovery after peripheral nerve repair is associated with increased levels of neurotrophic factors.
Park, JS; Hoke, A
Testing null
Activation and localization of matrix metalloproteinase-2 and -9 in the skeletal muscle of the muscular dystrophy dog (CXMDJ).
Fukushima, K; Nakamura, A; Ueda, H; Yuasa, K; Yoshida, K; Takeda, S; Ikeda, S
BMC Musculoskelet. Disord. null
Tina Nybo et al.
Redox biology, 20, 496-513 (2018-11-27)
Basement membranes are specialized extracellular matrices that underlie arterial wall endothelial cells, with laminin being a key structural and biologically-active component. Hypochlorous acid (HOCl), a potent oxidizing and chlorinating agent, is formed in vivo at sites of inflammation via the
Bicuspid aortic valve aortopathy is characterized by embryonic epithelial to mesenchymal transition and endothelial instability.
Freiholtz, et al.
Journal of molecular medicine (Berlin, Germany), 101, 801-811 (2023)
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