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Key Documents

AG714

Sigma-Aldrich

Human IgG, Fc Fragment

Synonym(s):

IgG Fc Fragment

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

human

Quality Level

antibody form

purified immunoglobulin

manufacturer/tradename

Chemicon®

shipped in

wet ice

target post-translational modification

unmodified

General description

Product Source: Human serum. Tested by an FDA approved test method and found negative for HIV antibody, Hepatitis B Surface Antigen, antibody to Hepatitis C and syphilis.

Application

Research Category
Controls

Physical form

Format: Purified
Sterile liquid in 0.01 M Sodium Phosphate, 0.25 M NaCl, pH 7.6. No preservatives have been added.

Storage and Stability

Store under sterile conditions at +2-8°C for up to one year. Dilute only as needed for a single day′s use.

Analysis Note

Single precipitin line by immunoelectrophoresis at 20 mg/mL against Goat anti-Human whole serum. No cross-reactivity against Goat anti-Human IgG F(ab′)2 fragment, IgM, Fc(5μ) or IgA, alpha-chain specific. Purified by column chromatography.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Iftiin Hassan Mohamed et al.
Pharmacological research, 64(5), 464-470 (2011-07-12)
The Eph tyrosine kinase receptors and their ephrin ligands play a central role in several human cancers and their deregulated expression or function promotes tumorigenesis, inducing aggressive tumor phenotypes. Green tea extracts (GTE) have been recently found to inhibit Eph-kinase
Frank Kung et al.
Investigative ophthalmology & visual science, 58(10), 4318–4331-4318–4331 (2017-08-15)
Rod photoreceptor terminals respond to retinal injury with retraction and sprouting. Since the guidance cue Semaphorin3A (Sema3A) is observed in the retina after injury, we asked whether Sema3A contributes to structural plasticity in rod photoreceptors. We used Western blots and
Delwin J Long et al.
Journal of molecular histology, 39(1), 1-4 (2007-07-27)
Immunohistochemical analysis of formalin-fixed paraffin-embedded tissues can be challenging due to potential modifications of protein structure by exposure to formalin. Heat-induced antigen retrieval techniques can reverse reactions between formalin and proteins that block antibody recognition. Interactions between antibodies and antigens
Enas Abu-Shah et al.
eLife, 8 (2019-09-26)
Research in the field of human immunology is restricted by the lack of a system that reconstitutes the in-situactivation dynamics of quiescent human antigen-specific T-cells interacting with dendritic cells. Here we report a tissue-like system that recapitulates the dynamics of
Sara C Humphreys et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(10), 1174-1182 (2019-05-18)
Understanding small interfering RNA (siRNA) fraction unbound (f u) in relevant physiologic compartments is critical for establishing pharmacokinetic-pharmacodynamic relationships for this emerging modality. In our attempts to isolate the equilibrium free fraction of N-acetylgalactosamine-conjugated siRNA using classic small-molecule in vitro

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