1.00495

Oxalic acid dihydrate

for analysis EMSURE^® ACS,ISO,Reag. Ph Eur

• Synonym(s): Oxalic acid dihydrate, Ethanedioic acid
• Linear Formula: (COOH)₂ · 2 H₂O
• CAS Number: 6153-56-6
• Molecular Weight: 126.07
• MDL number: MFCD00149102
• UNSPSC Code: 12352106
• EC Index Number: 205-634-3
• NACRES: NA.21

Properties

• grade: ACS reagent
• Quality Level: 300
• Agency: reag. ISO; reag. Ph. Eur.
• vapor pressure: 0.000312 hPa ( 25 °C)
• product line: EMSURE^®
• Assay: 99.5-102.0% (manganometric)
• form: solid
• potency: 375 mg/kg LD₅₀, oral (Rat)
• impurities: ≤50 ppm Insoluble matter
• ign. residue: ≤100 ppm (as sulfate)
• pH: 1.5 (10 g/L in H₂O)
• bp: 149-160 °C/1013 hPa (decomposition)
• mp: 98-100 °C
• transition temp: flash point 157 °C (decomposition)
• solubility: >100 g/L
• density: 1.65 g/cm³ at 20 °C
• bulk density: 813 kg/m³
• anion traces: chloride (Cl^-): ≤5 ppm; sulfate (SO₄^2-): ≤50 ppm
• cation traces: Ca: ≤10 ppm; Fe: ≤2 ppm; N: ≤10 ppm; heavy metals: ≤5 ppm; heavy metals (as Pb): ≤5 ppm
• storage temp.: 2-30°C
• SMILES string: [O+H3].[O+H3].[O-]C(=O)C(=O)[O-]
• InChI: 1S/C2H2O4.2H2O/c3-1(4)2(5)6;;/h(H,3,4)(H,5,6);2*1H2
• InChI key: GEVPUGOOGXGPIO-UHFFFAOYSA-N

Description

Application

• In Situ Investigation of a Self-Accelerated Cocrystal Formation by Grinding Pyrazinamide with Oxalic Acid.: This study investigates the in situ cocrystal formation of pyrazinamide and oxalic acid dihydrate, emphasizing the self-accelerating nature of the process and its implications for pharmaceutical development (Kulla et al., 2016).


• Deuterium MAS NMR studies of dynamics on multiple timescales: histidine and oxalic acid.: This article examines the dynamics of oxalic acid dihydrate and histidine using deuterium magnetic angle spinning nuclear magnetic resonance, providing insights into molecular motions on various timescales (Chan-Huot et al., 2015).

Analysis Note

Assay (manganometric): 99.5 - 102.0 %
Insoluble matter: ≤ 50 ppm
Chloride (Cl): ≤ 5 ppm
Sulfate (SO₄): ≤ 50 ppm
Total nitrogen (N): ≤ 10 ppm
Heavy metals (as Pb): ≤ 5 ppm
Heavy metals (ACS): ≤ 5 ppm
Ca (Calcium): ≤ 10 ppm
Fe (Iron): ≤ 2 ppm
Readily carbonisable substance: passes test
Residue on ignition (as sulfate): ≤ 100 ppm
Corresponds to ACS,ISO,Reag. Ph Eur

Legal Information

EMSURE is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302 + H312 - H318
• Precautionary Statements: P264 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338 - P362 + P364
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1