M-148

(±)-Metanephrine-D₃ hydrochloride solution

100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Synonym(s): (±)-Metanephrine-D₃ HCl
• Empirical Formula (Hill Notation): C₁₀H₁₂D₃NO₃·HCl
• CAS Number: 1215507-88-2
• Molecular Weight: 236.71
• EC Number: 200-659-6
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in methanol (as free base)
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing; clinical testing
• format: single component solution
• storage temp.: −70°C

Description

General description

Measurement of metanephrine, a metabolite of epinephrine, is a useful tool in the diagnosis of diseases such as pheochromocytoma and adrenal medullary neoplasm. This internal standard is suitable for LC-MS/MS monitoring of metanephrine levels in plasma or urine for diagnostic testing, endocrinology, or clinical chemistry.

Application

• High sensitivity catecholamine measurement: A study detailed the development of a high-sensitivity LC-MS/MS method for the measurement of 3-methoxytyramine, exploring its relationship with metanephrines and dopamine in plasma. This research underscores the utility of stable isotope-labeled compounds like (±)-Metanephrine-D₃ hydrochloride in biochemical assays related to catecholamine metabolism, offering significant insights for neurochemical analysis and drug development (Smy et al., 2021).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup