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Key Documents

V3204

Sigma-Aldrich

4-Vinylpyridine

contains 100 ppm hydroquinone as inhibitor, 95%

Synonym(s):

4-Ethenylpyridine Pyridine

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About This Item

Empirical Formula (Hill Notation):
C7H7N
CAS Number:
Molecular Weight:
105.14
Beilstein:
104506
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23

Quality Level

Assay

95%

contains

100 ppm hydroquinone as inhibitor

refractive index

n20/D 1.549 (lit.)

bp

62-65 °C/15 mmHg (lit.)

density

0.975 g/mL at 25 °C (lit.)

storage temp.

−20°C

SMILES string

C=Cc1ccncc1

InChI

1S/C7H7N/c1-2-7-3-5-8-6-4-7/h2-6H,1H2

InChI key

KFDVPJUYSDEJTH-UHFFFAOYSA-N

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General description

4-Vinylpyridine is a highly reactive alkene monomer due to the presence of a vinyl group and a heteroaromatic ring. It is widely used as a monomer to produce a variety of polymers and copolymers, which are used in various applications including, contact lenses, nanoelectronics, sensors, optoelectronic devices, smart coatings, drug delivery systems, sensors, gas separation, air filtration, and purification processes.

Application

4-Vinylpyridine can be used as a monomer:
  • In the synthesis or modification of polymers for drug-releasing contact lenses.
  • In the preparation of the zwitterionic polymer, namely poly(4-vinylpyridine propylsulfobetaine). The zwitterionic polymer is utilized for its superior bioinert capability in withstanding clinical sterilization processes, making it suitable for extended medical applications which include the development of biocompatible implants and as a coating material for medical devices.
  • To synthesize the temperature and pH-sensitive copolymer, specifically (N-vinylcaprolactam-co-4-vinylpyridine), which is used in drug delivery systems under certain environmental conditions.
  • The highly charged p(4-vinylpyridine-co-vinylimidazole) particles, which find applications in various fields such as biomedical, catalysis, and environmental applications.
4-Vinylpyridine also plays a role as a functional monomer in the molecular imprinting of the soft contact lens material. Its inclusion, along with other monomers, enhances the affinity of the hydrogel towards brimonidine, resulting in improved binding properties, loading capacity, and controlled release characteristics.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

125.0 °F - closed cup

Flash Point(C)

51.67 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Polymer, 34, 145-145 (1993)
Vusumzi Pakade et al.
Journal of chromatography. A, 1230, 15-23 (2012-02-22)
Molecularly imprinted polymers (MIPs) targeting quercetin were prepared from 4-vinylpyridine and ethylene dimethacrylate (EDMA) under various solvent systems with the aim to form MIPs with high recognition for the quercetin molecule in aqueous systems at high temperature. A MIP prepared
Chadin Kulsing et al.
Electrophoresis, 38(8), 1179-1187 (2017-02-18)
This investigation demonstrates the application of a new peak sharpening technique to improve the separation of difficult-to-resolve racemic mixtures in capillary electro-chromatography. Molecularly imprinted porous layer open tubular (MIP-PLOT) capillaries, prepared by a layer-on-layer polymerization approach with Z-l-Asp-OH as the
Yujuan Zhang et al.
BMC plant biology, 20(1), 45-45 (2020-01-31)
Wheat grain avenin-like proteins (ALPs) belong to a recently discovered class of wheat grain storage protein. ALPs in wheat grains not only have beneficial effects on dough quality but also display antifungal activities, which is a novel observation for wheat
Turghun Muhammad et al.
Analytica chimica acta, 709, 98-104 (2011-11-30)
Novel water-compatible molecularly imprinted polymers (MIPs) selective for amiodarone (AD) were designed via a new methodology which relies on screening library of non-imprinted polymers (NIPs). The NIP library consisted of eighteen cross-linked co-polymers synthesized from monomers commonly used in molecular

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