T7650

3,3′,5-Triiodothyroacetic acid

≥90%

• Synonym(s): 4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenylacetic acid
• Empirical Formula (Hill Notation): C₁₄H₉I₃O₄
• CAS Number: 51-24-1
• Molecular Weight: 621.93
• EC Number: 200-086-1
• MDL number: MFCD00055931
• UNSPSC Code: 12352100
• PubChem Substance ID: 57654700
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: ≥90%
• form: powder
• storage temp.: −20°C
• SMILES string: OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1
• InChI: 1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)
• InChI key: UOWZUVNAGUAEQC-UHFFFAOYSA-N
• Gene Information: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

Description

Application

• Thyroid hormone research: A study explored the impact of 3,3′,5-Triiodothyroacetic acid on peripheral and neurodevelopmental findings in patients with MCT8 deficiency, highlighting its potential in therapeutic interventions for thyroid-related developmental disorders (Unsal and Hayran, 2024).


• Neurological disorder management: Research demonstrated the use of 3,3′,5-Triiodothyroacetic acid in addressing impaired T3 uptake and action in cerebral organoids modeling Allan-Herndon-Dudley syndrome, providing insights into its application in managing brain-specific thyroid hormone transport abnormalities (Salas-Lucia et al., 2024).


• Pharmaceutical development for antiviral therapies: Tiratricol, a derivative of 3,3′,5-Triiodothyroacetic acid, was identified as an inhibitor of yellow fever virus replication by targeting the viral RNA-dependent RNA polymerase, showcasing its potential in antiviral drug development (Ren et al., 2023).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 + H312 + H332
• Precautionary Statements: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3