D120006
2,6-Dihydroxypyridine hydrochloride
97%
Synonym(s):
2,6-Pyridinediol hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C5H5NO2 · HCl
CAS Number:
Molecular Weight:
147.56
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
97%
form
solid
mp
206-208 °C (dec.) (lit.)
SMILES string
Cl[H].Oc1cccc(O)n1
InChI
1S/C5H5NO2.ClH/c7-4-2-1-3-5(8)6-4;/h1-3H,(H2,6,7,8);1H
InChI key
HNWWAWKDVFVJRG-UHFFFAOYSA-N
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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H Stopper et al.
Biochemical and biophysical research communications, 203(2), 1124-1130 (1994-09-15)
The rate limiting step in 5-fluorouracil catabolism is catalyzed by the enzyme dihydropyrimidine dehydrogenase. Since degradation of 5-fluorouracil decreases its efficacy in chemotherapy, the inhibition of its catabolism is a promising tool. We investigated the formation of micronuclei in vitro
Paula Sachelaru et al.
Journal of bacteriology, 187(24), 8516-8519 (2005-12-03)
The enzyme catalyzing the hydrolytic cleavage of 2,6-dihydroxypseudooxynicotine to 2,6-dihydroxypyridine and gamma-N-methylaminobutyrate was found to be encoded on pAO1 of Arthrobacter nicotinovorans. The new enzyme answers an old question about nicotine catabolism and may be the first C--C bond hydrolase
M Fukushima et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 23(6), 721-731 (1996-05-01)
Possible pathways of intracellular phosphorylation of 5-fluorouracil (5-FU) in human cancer cells were investigated in vitro and in vivo. We used two inhibitors which regulate the anabolism of 5-FU for the purpose of elucidation of its pathways; one is oxonic
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