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914460

Sigma-Aldrich

1-Biotinyl-3,6-dioxa-8-octaneamine hydrochloride

≥95%

Synonym(s):

1-Biotinyl-3,6-dioxa-8-octaneamine hydrochloride, N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide hydrochloride, N-{2-[2-(2- Aminoethoxy)ethoxy]ethoxy}biotinamide hydrochloride, Amine-terminated biotin linker, Biotin-DOOA HCl, Biotinylation reagent

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About This Item

Empirical Formula (Hill Notation):
C16H31ClN4O4S
CAS Number:
862373-14-6
Molecular Weight:
410.96
UNSPSC Code:
12352116
NACRES:
NA.22

Quality Level

100

Assay

≥95%

form

powder

storage temp.

2-8°C

Application

1-Biotinyl-3,6-dioxa-8-octaneamine hydrochloride is a versatile biotinylated linker that can be incorporated into chemical tools via its terminal amino group. Labeling materials or proteins with biotin provides a means to enrich and capture targets from biological systems.

Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

Other Notes

Efficient Innate Immune Killing of Cancer Cells Triggered by Cell Surface Anchoring of Multivalent Antibody-Recruiting Polymers

Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics

A Unified Framework for the Incorporation of Bioorthogonal Compound Exposure Probes within Biological Compartments

A Chemical Probe for Protein Crotonylation

One-Step Selective Exoenzymatic Labeling (SEEL) Strategy for the Biotinylation and Identification of Glycoproteins of Living Cells

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV2608
MKCV1544
MKCM4406

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Annemiek Uvyn et al.
Angewandte Chemie (International ed. in English), 58(37), 12988-12993 (2019-06-18)
Binding of monoclonal antibodies (mAbs) onto a cell surface triggers antibody-mediated effector killing by innate immune cells through complement activation. As an alternative to mAbs, synthetic systems that can recruit endogenous antibodies from the blood stream to a cancer cell
Benjamin Spangler et al.
ACS infectious diseases, 4(9), 1355-1367 (2018-05-31)
The Gram-negative cell envelope presents a formidable barrier to xenobiotics, and achieving sufficient compound exposure inside the cell is a key challenge for the discovery of new antibiotics. To provide insight on the molecular determinants governing compound exposure in Gram-negative
Kosuke Chiba et al.
Chemical communications (Cambridge, England), 53(62), 8751-8754 (2017-07-21)
We herein propose a simple affinity-labeling method using a ligand-4-azidophthalimide (AzPI) conjugate. As a proof of concept, we show that two different ligand-AzPI conjugates enabled highly specific fluorescence labeling of their individual target proteins even in crude cell lysates. This
Jeffrey Bos et al.
Journal of the American Chemical Society, 140(14), 4757-4760 (2018-03-28)
Protein lysine crotonylation has emerged as an important post-translational modification (PTM) in the regulation of gene transcription through epigenetic mechanisms. Here we introduce a chemical probe, based on a water-soluble phosphine warhead, which reacts with the crotonyl modification. We show
Tiantian Sun et al.
Journal of the American Chemical Society, 138(36), 11575-11582 (2016-08-20)
Technologies that can visualize, capture, and identify subsets of biomolecules that are not encoded by the genome in the context of healthy and diseased cells will offer unique opportunities to uncover the molecular mechanism of a multitude of physiological and
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