910023

3,6,9,12,15,18-Hexaoxahexacos-25-ynoic acid

• Synonym(s): 2-2-2-2-2-2-6 PROTAC^® linker, Alkyne-PEG₆-acid, Bifunctional linker
• Empirical Formula (Hill Notation): C₂₀H₃₆O₈
• Molecular Weight: 404.50
• UNSPSC Code: 12352106

Properties

• form: liquid
• reaction suitability: reagent type: linker
• functional group: alkyne; carboxylic acid
• storage temp.: 2-8°C
• SMILES string: OC(COCCOCCOCCOCCOCCOCCCCCCC#C)=O

Description

Application

This heterobifunctional, PEGylated crosslinker 3,6,9,12,15,18-hexaoxahexacos-25-ynoic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG₆-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-2-2-2-2-6.

Other Notes

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Partial PROTACs for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable