900768

Berkessel-Katsuki epoxidation catalyst

≥98%

• Synonym(s): Ti-Berkessel-Katsuki ligand complex, Titanium cis-1,2-diaminocyclohexane salalen catalyst
• Empirical Formula (Hill Notation): C₆₄H₄₀F₂₀N₄O₆Ti₂
• CAS Number: 2055468-23-8
• Molecular Weight: 1436.73
• UNSPSC Code: 12161600
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: ≥98%
• form: powder or crystals
• reaction suitability: core: titanium; reagent type: catalyst

Description

Application

Developed by Albrecht Berkessel′s lab, this is the first catalyst that allows catalytic enantioselective epoxidation of non-conjugated terminal double bonds with hydrogen peroxide as the oxidant. Eradicating multiple steps and kinetic resolution, this pre-formed chiral ligand-Ti₂O₂ catalyst complex provides a one-step route to enantiopure epoxides that are important intermediates for synthesis of bioactive compounds. Catalyst is recyclable under some conditions. For best results, pentafluorobenzoic acid P5360 or tetra-n-butylammonium hydrogensulfate 155837 is recommended as a co-catalyst.

Other Notes

Titanium cis-1,2-Diaminocyclohexane Salalen Catalysts of Outstanding Activity and Enantioselectivity for the Asymmetric Epoxidation of Nonconjugated Terminal Olefins with Hydrogen Peroxide

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable