779431

γ-Cyclodextrin

produced by Wacker Chemie AG, Burghausen, Germany, ≥90.0% cyclodextrin basis (HPLC)

• Synonym(s): Cavamax^® W8, gamma-Cyclodextrin, Cyclomaltooctaose, Cyclooctaamylose, Schardinger γ-Dextrin
• Empirical Formula (Hill Notation): C₄₈H₈₀O₄₀
• CAS Number: 17465-86-0
• Molecular Weight: 1297.12
• Beilstein: 78740
• EC Number: 241-482-4
• MDL number: MFCD00009595
• UNSPSC Code: 12352201
• PubChem Substance ID: 329768038
• NACRES: NA.22

Properties

• grade: produced by Wacker Chemie AG, Burghausen, Germany
• Quality Level: 200
• Assay: ≥90.0% cyclodextrin basis (HPLC)
• form: powder
• loss: ≤11.0% loss on drying
• functional group: ether; hydroxyl
• SMILES string: [H][C@]1(O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@@H]2[C@@H](COC(C)=O)O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O
• InChI: 1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1
• InChI key: GDSRMADSINPKSL-HSEONFRVSA-N

Description

General description

Gamma-cyclodextrin (γ-CD) is a cyclic α-1,4-glucan linked oligosaccharide that is widely used in the food and pharmaceutical industries. In drug delivery, γ-CD can be used as a complexing agent because it forms an inclusion complex with a drug molecule. The complex of cyclodextrin increases the aqueous solubility and dissolution rate of the drug, which is useful for the delivery of the medical agent to a biological system.

Application

γ-Cyclodextrin can be used as a precursor for the synthesis of:

• Octakis-(2,3-di-O-methyl-6-O-carboxymethyl)-γ-cyclodextrin sodium salt (ODMCM). ODMCM is used in capillary electrophoresis as a chiral resolving agent.
• Water-soluble cyclodextrin thioethers derivatives for the transportation of hydrophobic drugs.

Legal Information

Cavasol is a registered trademark of Wacker Chemie AG

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable