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53310

Sigma-Aldrich

Histamine bisphosphate monohydrate

≥99.0% (NT)

Synonym(s):

2-(4-Imidazolyl)ethylamine diphosphate salt, 2-(4-Imidazolyl)ethylamine diphosphate salt monohydrate, Histamine diphosphate salt monohydrate

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About This Item

Empirical Formula (Hill Notation):
C5H9N3 · 2H3PO4 · H2O
CAS Number:
51-74-1
Molecular Weight:
325.15
Beilstein:
3744619
EC Number:
200-118-4
MDL number:
MFCD00150816
UNSPSC Code:
12352005
eCl@ss:
32160406
PubChem Substance ID:
57651405
NACRES:
NA.22

Quality Level

100

Assay

≥99.0% (NT)

form

solid

mp

128-132 °C

functional group

amine
phosphate

storage temp.

−20°C

SMILES string

[H]O[H].OP(O)(O)=O.OP(O)(O)=O.NCCc1c[nH]cn1

InChI

1S/C5H9N3.2H3O4P.H2O/c6-2-1-5-3-7-4-8-5;2*1-5(2,3)4;/h3-4H,1-2,6H2,(H,7,8);2*(H3,1,2,3,4);1H2

InChI key

CNSGLKZGHLZDHQ-UHFFFAOYSA-N

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General description

Histamine bisphosphate monohydrate is an imidazole containing heterocyclic building block that can be employed in chemical synthesis. Its crystal structure belongs to the monoclinic space group, P21/c and shows O–H ? O and N–H?O hydrogen bonds.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ7850
BCBN6122V
1316643V
BCBC2083V
1316643

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Crystal structure of histamine diphosphate monohydrate.
Veidis MV, et al.
J. Chem. Soc. Sect. A, 2659-2666 (1969)
L Shall et al.
Acta dermato-venereologica, 71(3), 199-204 (1991-01-01)
Terfenadine is a safe non-sedative H1-receptor antagonist. This study aimed to quantify the relative reduction in weal and flare area, thickness and erythema at 4, 8, 12 and 24 h following a single but variable oral dose of terfenadine compared
L Shall et al.
Acta dermato-venereologica, 72(6), 451-453 (1992-11-01)
This study examined cutaneous mast cell behaviour in 14 patients with chronic urticaria but no dermographism and 11 healthy controls, by measuring cutaneous weal and flare reactions evoked in response to intradermal challenge injections of 0.1 ml isotonic saline, histamine
H S Nelson et al.
The Journal of allergy and clinical immunology, 92(5), 750-756 (1993-11-01)
Five commercially available devices for performing prick skin testing were compared for reproducibility, patient acceptance, occurrence of false-negative skin test results, and size distribution of reactions at the negative control sites. Reproducibility of skin testing with 10 mg/ml histamine base
Y Larivée et al.
The Journal of otolaryngology, 30(6), 319-323 (2002-01-05)
The objectives of this study were to evaluate the reproducibility of the nasal response to histamine with the acoustic rhinometer and to compare the responses in normal and rhinitic subjects. Our study comprised 10 normal and 10 rhinitic subjects. Each
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