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162604

Sigma-Aldrich

4-Hydroxy-3-methoxybenzonitrile

98%

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About This Item

Linear Formula:
HOC6H3(OCH3)CN
CAS Number:
4421-08-3
Molecular Weight:
149.15
EC Number:
224-589-0
MDL number:
MFCD00001820
UNSPSC Code:
12352100
PubChem Substance ID:
24849995
NACRES:
NA.22

Assay

98%

form

solid

mp

85-87 °C (lit.)

functional group

nitrile

SMILES string

COc1cc(ccc1O)C#N

InChI

1S/C8H7NO2/c1-11-8-4-6(5-9)2-3-7(8)10/h2-4,10H,1H3

InChI key

QJRWLNLUIAJTAD-UHFFFAOYSA-N

General description

4-Hydroxy-3-methoxybenzonitrile on treatment with sodium perborate yields 4-hydroxy-3-methoxybenzamide.

Application

4-Hydroxy-3-methoxybenzonitrile was used in the synthesis of 1,5-bis(4-cyano-2-methoxyphenoxy)-3-oxapentane.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBK9917
STBK2341
STBJ3304
STBC2794V
STBC0272V

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Dorota Maciejewska et al.
European journal of medicinal chemistry, 48, 164-173 (2011-12-28)
A series of 20 pentamidine analogs were prepared using 2 general Schemes that evaluated heteroatoms, sulfobenzene and alkanediamide groups in the aliphatic linker and methoxy substituents attached to the benzene rings for efficacy against the fungal pathogen, Pneumocystis carinii in
Jerzy W Jaroszewski et al.
Natural product research, 19(3), 291-294 (2005-02-11)
Extract of Naravelia zeylanica (Ranunculaceae) yielded three simple benzamides, 3,4-methylenedioxybenzamide, 4-methoxybenzamide and 4-hydroxy-3-methoxybenzamide. These simple C6C1 metabolites have been encountered as natural products for the first time. The compounds were identified by direct comparison of their spectral (1H- and 13C-NMR)

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