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147826

Sigma-Aldrich

5,6-Dimethoxy-1-indanone

97%

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About This Item

Empirical Formula (Hill Notation):
C11H12O3
CAS Number:
Molecular Weight:
192.21
Beilstein:
1241095
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

97%

form

solid

mp

118-120 °C (lit.)

functional group

ketone

SMILES string

COc1cc2CCC(=O)c2cc1OC

InChI

1S/C11H12O3/c1-13-10-5-7-3-4-9(12)8(7)6-11(10)14-2/h5-6H,3-4H2,1-2H3

InChI key

IHMQOBPGHZFGLC-UHFFFAOYSA-N

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General description

Thiosemicarbazone derived from 5,6-dimethoxy-1-indanone inhibits bovine viral diarrhea virus infection.

Application

5,6-Dimethoxy-1-indanone was used in the synthesis of 2,3-dimethoxy-11H-indeno[1,2-b]quinoline-6,10-dicarboxylic acid.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Eliana F Castro et al.
Journal of virology, 85(11), 5436-5445 (2011-03-25)
In the present work, we described the activity of the thiosemicarbazone derived from 5,6-dimethoxy-1-indanone (TSC), which we previously characterized as a new compound that inhibits bovine viral diarrhea virus (BVDV) infection. We showed that TSC acts at a point of
L W Deady et al.
Bioorganic & medicinal chemistry, 7(12), 2801-2809 (2000-02-05)
A series of ring-substituted analogues of the topoisomerase inhibitor 11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides was prepared and evaluated. The compounds were prepared by Pfitzinger reaction of the appropriate isatin-7-carboxylic acids and 1-indanones, followed by selective thermal decarboxylation of the resulting tetracyclic diacids, subsequent oxidation
María C Soraires Santacruz et al.
Bioorganic & medicinal chemistry, 25(15), 4055-4063 (2017-06-11)
A series of N
Daniel I Perez et al.
Bioorganic & medicinal chemistry, 17(19), 6914-6925 (2009-09-15)
Thienylhalomethylketones, whose chemical, biological, and pharmaceutical data are here reported, are the first irreversible inhibitors of GSK-3beta described to date. Their inhibitory activity is likely related to the cysteine residue present in the ATP-binding site, which is proposed as a

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