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About This Item
Empirical Formula (Hill Notation):
C12H15N3O
CAS Number:
Molecular Weight:
217.27
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Quality Level
Assay
98%
form
solid
mp
183-185 °C (lit.)
SMILES string
O=C1Nc2ccccc2N1C3CCNCC3
InChI
1S/C12H15N3O/c16-12-14-10-3-1-2-4-11(10)15(12)9-5-7-13-8-6-9/h1-4,9,13H,5-8H2,(H,14,16)
InChI key
BYNBAMHAURJNTR-UHFFFAOYSA-N
Application
4-(2-Keto-1-benzimidazolinyl)piperidine was used to study the structure–activity relationships with several potent and selective analogues.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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P Zhang et al.
Bioorganic & medicinal chemistry letters, 11(20), 2747-2750 (2001-10-10)
Novel 6-aryl benzimidazolones and benzothiazolones were prepared and examined as bioisosteres of the recently reported 6-aryl dihydroquinolines (1) for progesterone receptor (PR) antagonist activities. PR antagonist activities increased when compounds 9c-f possessed a more lipophilic group at position-1 and pendent
Eduard Badarau et al.
Bioorganic & medicinal chemistry letters, 19(6), 1600-1603 (2009-02-25)
A new group of serotoninergic 5-HT(1A) or 5-HT(7) receptor ligands was identified. These compounds were designed and synthesized on a benzimidazolone scaffold and they enrich the well-known arylpiperazine class of 5-HT ligands. Diverse pharmacomodulations induced a shift in the affinity
Ronald Palin et al.
Bioorganic & medicinal chemistry letters, 15(3), 589-593 (2005-01-25)
A series of 3-phenoxypropyl piperidine analogues have been discovered as novel ORL1 receptor agonists. Structure-activity relationships have been explored around the 3-phenoxypropyl region with several potent and selective analogues identified.
Ho Yin Lo et al.
Bioorganic & medicinal chemistry letters, 21(15), 4533-4539 (2011-07-08)
A new class of chymase inhibitor featuring a benzimidazolone core with an acid side chain and a P(1) hydrophobic moiety is described. Incubation of the lead compound with GSH resulted in the formation of a GSH conjugate on the benzothiophene
Rapid liquid-phase combinatorial synthesis of heterocyclic libraries.
Chung-Ming Sun
Methods in molecular biology (Clifton, N.J.), 201, 141-166 (2002-10-03)
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