T6700

TRAM-34

≥98% (HPLC), solid

• Synonym(s): 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
• Empirical Formula (Hill Notation): C₂₂H₁₇ClN₂
• CAS Number: 289905-88-0
• Molecular Weight: 344.84
• MDL number: MFCD09842562
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826852
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: 2 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
• InChI: 1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
• InChI key: KBFUQFVFYYBHBT-UHFFFAOYSA-N

Description

Application

TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

Biochem/physiol Actions

TRAM-34 exhibits 100-fold selectivity (K_d = 20 nM) for IK_Ca1 channels over other K⁺ channels (Charybdotoxin, K_d = 5 nM, Clotrimazole, K_d = 70 nM; Nitrendipine K_d = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.

TRAM-34 is a potent inhibitor of the intermediate-conductance Ca²⁺-activated K⁺ channel.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H413
• Precautionary Statements: P264 - P270 - P273 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves